Endocrine Abstracts

Background and objectives: The finding of a thyroid nodule is a very common occurrence in clinical practice. Management of thyroid nodules requires a multidisciplinary approach that may be eased by a high-resolution thyroid nodule clinic. We report our clinical experience and outcomes in a high-resolution thyroid nodule clinic.Materials and methods: We conducted a retrospective analysis of 1674 thyroid nodules evaluated in a high-resolution clinic from a...

Introduction: Glycemic variability (GV) has been associated, regardless to A1C levels, to chronic complications of diabetes mellitus (DM).Objective: To describe baseline characteristics, GV parameters, and microvascular complications rates in a selected simple of type 1 diabetes patients (T1DM) on continuous subcutaneous insulin infusion (CSII).Methods: We performed a retrospective observational study with 130 T1DM patientson (CSII...

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

Introduction: In patients with type 1 diabetes, exercise has not consistently been shown to improve glycemic control, as measured using HbA1c levels. Participation in competitive sports may even worsen glycaemic control. Free radicals and oxidative stress markers are known to increase during acute exercise in parallel to decreased circulating antioxidant concentrations. We aimed to analyze the effects of chronic and acute exercise on circulating HbA1c and fructosamine levels.<...

Background and objectives: Evaluate the impact of therapy with GLP-1 analogues (liraglutide) on glycemic control and weight in patients with type 2 diabetes and poor metabolic control.Material and methods: We conducted a retrospective observational study analyzing 67 patients with type 2 diabetes mellitus and BMI >30 kg/m2, over 6 months of treatment. We evaluated HbA1c and weight at 3 and 6 months, performing statistical analysis with SPS...

Introduction: Maternal obesity is associated with increased risk of metabolic dysfunction in the offspring. It is not clear which physiological aspects of the obese state that cause this metabolic programming. Obesity causes many metabolic changes but also low grade inflammation. In this study, we have determined if increased low grade inflammation was present in obese dams compared to controls dams during gestation.Methods: Female C57BL/6 mice were fed ...

Generously supported by IPSEN)-->GH replacement (GHR) in adults has demonstrated to improve body composition, inflammatory cardiovascular biomarkers and quality of life. However, this benefit is uneven, and factors that stratify treatment response are required.According to current guidelines, low IGF-I levels in specific conditions provide strong evidence for GH deficiency (GHD). Nevertheless, normal levels do ...

Introduction: Childhood-onset hypopituitarism is an uncommon yet increasingly diagnosed disorder. As endocrinologists, we generally deal with the complexities of hormonal replacement and, when required, follow these patients to detect tumor recurrences. However, some causes of childhood- onset-hypopituitarism have comorbidities which can significantly increase morbi-mortality. We present the case of a 21-year-old girl who was diagnosed with ROHHAD syndrome.<p class="abstex...

Thyroid hormones (TH) are required for normal postnatal growth development in mammals. The physiological importance of TH becomes evident under the conditions of congenital–neonatal hypothyroidism (CH). If not treated immediately, CH has a profound impact on physiology and can permanently imprint neurological and endocrine systems, which, in turn, led to mental retardation, growth arrest, and metabolic disturbances. A delayed growth development or long-lasting influence o...

Introduction: Neuroendocrine lesions in the thyroid gland are uncommon. The differential diagnosis usually includes medullary thyroid carcinoma, paraganglioma and metastases. There are few non-conclusive reports of primary neuroendocrine carcinomas of the thyroid.Clinical case: A 49-year-old woman with a past medical history for familial hypercholesterolemia and right oophorectomy for mature teratoma with struma ovarii, was evaluated for a rapidly growin...