Endocrine Abstracts

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to 3 different hospitals in Cádiz province with acute coronary syndrome and diabetes in 2016. Demographic data an...

Introduction: Persistent hyperinsulinemic hypoglycemia may be caused either by a solitary tumor of the pancreas secreting excessive amount of insulin, known as insulinoma or, rarely, by nesidioblastosis. Nesidioblastosis is a rare cause of persistent hyperinsulinemic hypoglycemia in adults.Methods: We describe the case of a 25-year-old male patient who was referred to our clinic for repeted hypoglycemia episodes.Results: Our patien...

Introduction: MODY 5 is a rare type of dominantly inherited diabetes mellitus. It is asociated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene. They are mostly missense mutations that produce truncated proteins with a variable clinical spectrum that encompasses among others: kidney, genital and pancreatic abnormalities.Case-report: A 35 years-old man without relevant medical history, presented with acute hypergycemia (541 mg/dl) an...

Backgrounds and aims: The aims of the study were, on the one hand, to analize the prevalence of type 2 diabetes mellitus in a population of institutionalized older people and, on the other hand, to evaluate if the anthropometric parameters and the prevalence of malnutrition and sarcopenia were different in diabetic patients compared with the group of non-diabetics.Methods and material: A total of 312 institutionalized elderly people volunteers with a mea...

Introduction: Reports of pregnancy occurring in acromegalic patients are uncommon. Nevertheless, it appears that women are usually able to carry their pregnancy to full termCase: 39 year old woman referred to endocrinology for secondary amenorrhea and hyperprolactinemia (PRL 55.54 mg/dl). As she mentioned typical symptoms of Acromegaly, we extended the study, finding high levels of IGF1 and a pituitary macroadenoma (25×16 mm) in MRI. Presurgical tre...

The defective conversion of testosterone to dihydrotestosterone due to a steroid 5-alpha-reductase 2 deficiency results in a unique form of 46, XY disorder of sexual development (DSD). Dihydrotestosterone is essential for the embryonic differentiation of the external male genitalia and the prostate. Steroid 5-alpha-reductase 2 deficiency is an autosomal recessive disorder in which genetic males have a predominantly female phenotype with female external genitalia but male inter...

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

Although the effect of aging on adipose tissue metabolism have been thoroughly studied for years, changes in the antilipolytic action of insulin in visceral white adipose tissue from aged rats are still not completely understood. By fact, some contradictory data on the inhibition of isoproterenol-induced lipolysis by insulin with aging have been reported. As aging is a significant risk factor for increasing adiposity and the development of obesity, we hypothesized that the inh...

Clinical case: We report the case of a 40-year-old woman, diagnosed with sporadic medullary thyroid carcinoma (MTC) treated with total thyroidectomy, cervical lymph node dissection and chemotherapy. During follow-up, cervical lymph node, lung, breast, bone and subcentimeter cerebellous affectation was observed. She started on Sunitinib, but withdrawal at 6 months due to severe inguinal inverse psoriasis. Then, treatment with vandetanib was started with good response. Tumor mar...

Introduction: Follicular neoplasm (FN) or suspicious for a follicular neoplasm category is established by The Bethesda System for Reporting Thyroid Cytopathology because of the necessity to identify a nodule that might be a follicular carcinoma and triage it for surgical lobectomy. Estimated risk of malignancy for this category is 15–30%.Description of methods: We conducted a retrospective study that included all patients with a follicular neoplasm ...