Endocrine Abstracts

Objectives: Our aim is to assess the cardiovascular risk factors that are already present at the time of diagnosing new-onset type 2 diabetes mellitus (DM).Materials and methods: This was an observational study. From each patient the following data were retrospective collected between January 2008 and September 2009: age, sex, DM in the family, smoking, HbA1c, hypertension (HTA) and dyslipidemia, microangiopathy and macroangiopathy, lipids and medical tr...

Pseudohypoparathyroidism (PHP) is a term applied to a heterogeneous group of disorders whose common feature is resistance to parathyroid hormone. Most of the PHP forms are caused by defects in GNAS: PHP-Ia (characterized by PTH and TSH resistance with Albright Hereditary Osteodystrophy) is caused by heterozygous inactivating mutations in those exons of GNAS encoding the α subunit of the stimulatory G-protein, and the autosomal dominant form of PHP-Ib (PTH an...

Objective: To evaluate the main clinical characteristics and the obstetrical results of perinatal morbi-mortality of women with gestacional diabetes in our Service.Material and method: We made a descriptive study of 83 gestational diabetes patients which became a pursuit coordinated between the services of Endocrinology and Gynecology. The following main aspects were analyzed: age, toxic habits, BMI pre-gestational, first pregnancy or not, previous antec...

Objectives: To verify the results of the insulin treatment intensification in the control of Diabetes Mellitus type 1 and 2 (DM1 and DM2).Methodology: Of 100 diabetic patients (30% DM1 and 70%DM2) derived to Day Diabetes Hospital (DDH) by glycemic decompensation during year 2007 were studied, 45% women and 55% men (we excluded the debut). The average age of the patients was of 35.1 years in DM1 and 64.4 years in DM2. The Hba1c in the first visit and to t...

Background: Acromegaly, a chronic disease caused by excess secretion of growth hormone (GH), has been known to reduce patients life expectancy. This increase in morbility and mortality is not only due to cardiovascular, respiratory or cerebrovascular disorders, but also to an increased risk for cancer.Subjects and methods: The aim of this study was to describe the associated malignant diseases among our fifty acromegalic patients. Clinical features of th...

Metabolic syndrome and insulin resistance persist 5 years after remission of Cushing’s syndrome (CS). Adiponectin and visfatin are two adipokines highly expressed in adipose tissue. Adiponectin is reduced in obesity and insulin-resistant states; visfatin has been shown in some studies to be reduced in obesity. The aim was to evaluate visfatin and adiponectin levels, body composition, insulin resistance and prevalence of metabolic syndrome in a cohort of women with long-te...

We aimed to assess the effect of sleeve gastrectomy (SG) on the metabolic and gut microbiota profiles in non-diabetic obese patients with different grade of insulin resistance (IR).Methods: Prospective study of 22 morbid non-diabetic obese patients (77.2% women, age 47.13±9.51 years, basal BMI 45.59±4.99 kg/m2, 11 IR and 11 non-IR) undergoing SG. A fasting blood sample was collected at baseline and at 6 months post-SG for the determi...

Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients with and without diabetes mellitus (DM). Traditional cardiovascular risk factors fail to fully account for the increase in cardiovascular risk in these patients. The NEFRONA study is a large, multicentre, prospective, observational study that evaluated atheromatous disease (AD) in the carotid and femoral territories in a large cohort of Spanish CKD ...

Objective: To evaluate the effectiveness and security of bariatric surgery in metabolically healthy obese (MHO).Methods: A retrospective study of a cohort of all obese patients who underwent to bariatric surgery with a minimum two-year follow-up. Databases of all demographic, anthropometric and metabolic characteristics have been collected since 2007. Patients undergoing two surgeries were excluded. We defined as MHO patients those without diagnosis of d...

PurposeTo evaluate the prevalence of bilateral macronodular adrenal hyperplasia (BMAH) in patients with adrenal incidentalomas (AIs) and analyse the differential phenotype of patients with BMAH compared to other bilateral adrenal lesions which do not meet BMAH definition (non-BMAH), with associated possible or confirmed autonomous cortisol secretion (ACS).MethodsRetrospective study of patients with AIs diagno...