Endocrine Abstracts

Transsphenoidal adenomectomy (TSA) is the recommended primary therapy in most patients with acromegaly and results in remission for majority of microadenomas and a proportion of macroadenomas depending on extent of surgically accessible disease. Acromegaly is associated with significant mortality and morbidity, hence a combination of treatment modalities may be needed to achieve disease control.Methods: A retrospective casenotes review was conducted and ...

Introduction: 25-hydroxyvitamin D (25(OH)D3) deficiency has been associated with diabetes and obesity. However, the mechanisms underlying these relationships are not completely understood. Vitamin D receptor (VDR) is expressed in adipose tissue; it has been reported a higher expression in obese patients than in lean subjects, suggesting a differential vitamin D dynamics in adipose tissue according to the obesity degree. In addition, 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) is a...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of cardiovascular complications. It is, also, well known that diabetes confers a substantial burden of microvascular disease. Previous studies suggest a link between microvascular and macrovascular events in diabetes. However, just a few studies have investigated whether the presence of previous cardiovascular events is associated with microvascular disease in diabetes patients. So, this is th...

Introduction: Hyponatremia is the most common electrolyte imbalance among hospitalised patients. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered the most frequent etiology on patients with euvolemic hiponatremia. Conventional treatment includes water restriction and salt tablets with limited efficacy and very slow onset of action in certain patients.Material and methods: Systematic sampling of all SIADH patients treated wit...

Aim: To evaluate whether differences exist in terms of patient, radiological, tumour characteristics and surgical complications between malignant and benign thyroidectomy.Materials and methods: 184 correlatives cases of thyroidectomy during the period from October 2011 to October 2013 are analysed. Patient, ultrasound, tumour and complication characteristics are compared. Categorical data are reported as percentages. Characteristics between the two group...

Introduction: Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt signaling and bone formation. The usefulness of its determination in clinical practice is not well established.Objectives: The aims of this study were to evaluate serum sclerostin levels in a cohort of Spanish posmenopausal women, and to analyze its relationship with bone metabolism.Methods: We measured serum sclerostin in 97 posmenopausal women using EL...

Introduction: The syndrome of late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age male, characterized by typical symptoms and decreased serum concentrations of testosterone, which can affect multiple organ systems and may impair quality of life. The prevalence of LOH syndrome is higher in certain patient groups, obese, diabetic and suffering from erectile dysfunction manifest LOH at higher rates than the general population.<p ...

Introduction: Dumping syndrome is a phenomenon produced by the alteration of the pyloric sphincter. It occurs in 20% of pyloroplasty or distal gastrectomies. The syndrome is attributed to the rapid emptying of the chyme in the intestine. The osmotic gradient attracts fluid to the intestine, and this releases vasoactive hormones, such as serotonin or vasoactive intestinal polypeptide.Case report: We present a 82-year-old woman with gastric intervention in...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 20 patients with primary hyperparathyroidism who had complete at least 12 months of treatment with cinacalcet for different reasons (eight patients r...

Objective: Relationship between pre-pregnancy BMI (PPBMI) in gestational diabetic (GD) patients, and age, country of origin, family history of type 2 diabetes mellitus (T2DM), GD history, and BMI after pregnancy.Methods: Transversal, descriptive study of 259 consecutive pregnant with confirmed DG. Analysis were based on Fisher’s exact test and Student’s t-test. A P<0.05 was significant (SPSS 19.0).Re...