Endocrine Abstracts

Objectives: To evaluate the characteristics of patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting and to analyze associated antidiabetic treatment and metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about age, sex, body mass index (BMI), associated antidiabetic treatment, and HbA1c was collected.Results: Seventy nin...

Objectives: To evaluate the use of antidepressant drugs in patients with type 2 diabetes mellitus (T2DM) and to analyse if these drugs are associated with a more deteriorated metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, T2DM evolution, body mass index (BMI), HbA1c and associated antidepressant treatment was collected. Statistical analysis was performed with SPS...

Objectives: To evaluate the degree of control of atherogenic dyslipidaemia in patients with type 2 diabetes mellitus (T2DM).Methods: Retrospective cohort study which included patients with T2DM followed in a primary care setting. Patients were classified according to the following criteria: strict control of dyslipidaemia (LDL <100 mg/dl and triglycerides <150 mg/dl), partial control of dyslipidaemia (LDL ≥100 mg/dl or triglycerides ≥...

Introduction: There are new therapies indicated in medullary thyroid cancer (MTC) based on different molecular targets, that appear to be effective in some cases with advanced disease, although many are still under investigation.Material and methods: We retrospectively evaluated five cases of medullar thyroid advanced carcinoma that later were referred to Oncology Department for Chemotherapy treatment.Results: Five patients (mean a...

Differentiated thyroid carcinoma is the most common endocrine malignant tumor. Papillary carcinoma frequency in our country is 80% of thyroid neoplasia. Papillary thyroid carcinoma usually metastasizes to cervical lymph. Metastases to distant organs are rare and most often affect the lungs, liver and bones. Despite of its anatomical proximity, metastasis parotid have not been described in the existing papillary carcinomas literature. We report a case of parotid gland metastasi...

Background: Parathyroid carcinoma accounts for <1% of cases of primary hyperparathyroidism. Clinical presentation is usually related to severe hypercalcemia associated to elevated serum PTH (three times above the upper limit). These values are so much higher than in primary hyperparathyroidism due to a benign adenoma. Moreover, 30–75% of patients had a palpable neck mass.Clinical case: Fifty one-year-old male, submitted to bariatric surgery by a...

PTSD is an anxiety disorder that occurs among persons exposed to a traumatic event involving life threat and injury. This is a co-morbid psychiatric disorder that occurs along with depression. Cortisol, secreted in the adrenal cortex in response to stress, is an informative biomarker that distinguishes anxiety disorders such as major depression and post-traumatic stress disorder (PTSD) from normal subjects. In comparison to normal subjects, hypocortisolemia was observed during...

Introduction: Some metabolic diseases, including type 1 (T1DM) and type 2 (T2DM) diabetes mellitus have an influence on bone homeostasis. These facts are of great socio-medical impact, since currently the DM2 and osteoporosis are considered public health problems.Objectives: (1) Determine the relationship between markers of bone metabolism and insulin resistance in postmenopausal women with and without T2DM.(2) Compare the bone min...

Introduction: Primary hyperparathyroidism (PHPT) is emerging as a cause of secondary hypertension. Between 20 and 50% of patients with PHPT have hypertension, this being directly proportional to the calcemia. The elevation of blood pressure in PHPT is mediated by hypercalcemia that acts directly stimulating the contraction of muscle fibers of the arterial vessel wall, and increases plasma renin levels and the release of catecholamines.Objectives: (1) Det...

Pseudohypoparathyroidism (PHP) refers to a group of heterogeneous genetic diseases, characterized by resistance to PTH and frequently other hormones activating cAMP-dependent events down-stream of different G protein-coupled receptors. PHP-Ia and Ib, the most frequent forms, are caused by mutations within the GNAS locus that encodes Gαs and several splice variants thereof. We describe a 36-year-old man with sporadic PHP-Ib with renal PTH-resistance, yet severe hyperparath...