Endocrine Abstracts

Background: Overt parathyroid bone disease is a rare entity. We present a case of primary hyperparathyroidism (PHPT) and osteitis fibrosa cystica with involvement of multiple facial bones and neurocranium. Although the initial differential diagnosis was between acromegaly and bone malignancy, endocrine assessment demonstrated PHPT, with favorable outcome after parathyroidectomy.Case report: A 59-year-old woman referred to our clinic with painful swelling...

Background: PA is a clinical syndrome secondary to hemorrhage or infarction of pituitary tumour, presenting with sudden onset headache and oculomotor palsy. PA may be managed conservatively in patients without visual disturbances.Aim: To describe PA patients illustrating typical aspects and peculiarities.Results: Case 1, a 49 years old (yo) male, presented for loss of consciousness in the ER. MRI showed a giant pituitary tumour, wh...

Background: Surgery is the standard treatment in patients with medullary thyroid carcinoma (MTC), 43% being biochemically cured postoperative in a large series, the most important prognostic factor being the stage of the disease.Material and methods: We present 3 cases of biochemical cured patients after surgery with different preoperative presentation. Calcitonin and carcinoembryonic antigen (CEA) were measured by chemiluminescence. Histological examina...

Introduction: The incidence of parathyroid carcinoma in primary hyperparathyroidism is less than 1% and the association with ACTH-independent Cushing syndrome is very rare.Case report: A 40-year-old female was admitted for weight gain and reddish-purple striae. One month earlier she had a ¾ parathyroidectomy for primary hyperparathyroidism with histopathological examination showing a parathyroid carcinoma and two parathyroid adenomas. She also had a...

Introduction: Acromegaly has various complications that significantly alter patients’ lives, one of which is developing neoplasia, a subject of high interest in the scientific community during the last years but without any firm conclusions.Aim: The main objective of this paper was to verify if Romanian acromegalic patients are susceptible to developing neoplasia and what types of tumors are associated with acromegaly. Another purpose of the paper w...

Objective: Patients with pituitary macroadenomas and concomitant hypopituitarism have a reduced life expectancy due to various comorbidities.Aim: To investigate mortality in patients with non-functioning pituitary adenomas (NFAs) and independent prognostic factors influencing survival.Design: Retrospective cohort study in a tertiary neuroendocrine university department.Methods: A total of 364 patients (177F/1...

Background: Active acromegaly is characterized by decreased insulin sensitivity (ISen). However, insulin secretion (ISec) may not increase satisfactorily to compensate for the low ISen.Aim: To assess ISen and ISec and to calculate disposition index (DI) using an intravenous glucose tolerance test (IVGTT) in patients with active acromegaly.Methods: Twelve patients (7 men, 5 women) with active acromegaly and 2 normal subjects (2 men)...

Background: Prevalence and type of amiodarone-induced thyroid dysfunction in a population depend on geographical iodine intake.Aims: To assess differences in amiodarone-induced thyrotoxicosis pattern before and after iodine supplementation.Patients and methods: 84 patients (41M/43F) with amiodarone-induced thyrotoxicosis, aged 60.1±11.9 years, were retrospectively reviewed. 28 patients were resident in former iodine-deficient ...

Background: Screening for primary aldosteronism (PA) needs aldosterone-to-renin ratio (ARR) measurement, followed by confirmative tests.Aim: To assess the clinical value of captopril challenge test (CCT) in PA diagnosis.Methods: Thirty patients were screened for secondary endocrine hypertension; study group consisted in 15 PA patients (7M/8F, aged 44.6±13.3 years). Control group consisted in 15 patients (5M/10F) with negative ...

Introduction: Primary aldosteronism is associated with increased prevalence of cardiometabolic complications. The mechanisms are not fully elucidated, but an association with autonomous cortisol secretion could increase vascular and metabolic risk.Aims: To assess glucocorticoid axis in patients with primary aldosteronism as compared to patients with ACTH-independent Cushing syndrome and control hypertensive patients without gluco or mineralocorticoid exc...