Endocrine Abstracts

Introduction: Severe hyperandrogenism is not only associated with cosmetic concerns but it also increases the risk of neoplastic (endometrial, breast cancer), cardiovascular, respiratory and metabolic complications.Case report: A 68 years-old woman with a recent history of severe arterial hypertension, cardiogenic pulmonary edema, diabetes mellitus, severe respiratory failure, marked obesity was referred to our department due to the markedly androgenic p...

Introduction: Ectopic thyroid tissue (ETT) is a rare entity; it is more frequent in women (80%) and is usually located along the obliterated thyroglossal duct. ETT in the midline is even rarer (1.79%). Incidence of malignancy in this group is lower than in orthotopic thyroid nodules.Case report: A 40 years old woman, resident in iodine sufficient area, but originating from an iodine deficient area, presented for a midline neck mass. TSH and FT4 were meas...

Background: Thyroid nodules were reported with high prevalence in acromegalic patients.Patients and methods: 63 acromegalic patients (16 males and 47 females), aged at diagnosis 43.6±12.7 years were retrospectively reviewed. Median duration of acromegaly was 8 years. 25 patients were residents in iodine deficient areas. GH, IGF1, TSH, FT4 were measured by chemiluminescence (Liaison). Thyroid ultrasound was performed. In suspected nodules,...

Aim: Re-analysing the effect of injectable testosterone undecanoate depot (TUD) in hypogonadic patients.Materials and method: (A) Patients: at onset 210 men with hypogonadism (median age: 61.5 years). (B) Distribution: by decade; n=4, 12, 21, 54, 59, 43, 16, and 1. (C) TUD (NebidoR-Bayer-Schering) 1000 mg was injected one per 3 months i.m. (D) Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5 MHz probe, elliptical volume (cm...

Aim: To find if testosterone undecanoate (TUD) 1000 mg injection (NebidoR; Bayer-Schering) at 3 months has a negative effect on prostate.Materials and method: i) PSA (ng/ml) registred before (T0) and after TUD at T1 (2 weeks) to T10 (7 years) (see Pisoschi, this Congress); ii) statistical analysis: t-test, simple correlation, and multiple regression.Results: (A) Patients at onset: 143 men, 18–96 years, average: 60.38;...

Introduction: An improvement of survival in patients with acromegaly was claimed in the last years, with multimodal new therapies.Aims: To assess cure rates of different therapeutic protocols and the impact of these therapies on survival.Methods: 334 patients (224 F/110 M, mean age 48.1±0.7 years) with acromegaly admitted in a single Neuroendocrinology Department between Jan 2001 and Dec 2013 were retrospectively studied by GH...

Introduction: We should consider testing for primary aldosteronism in the presence of hypertension and hypokalaemia, resistant hypertension, onset of hypertension at a young age (<20 year), severe hypertension and whenever considering secondary hypertension.Case report: We presented the case of a 38 years old woman who was admitted in the National Institute of Endocrinology C.I. Parhon Bucharest for the evaluation of high blood pressure. She has high...

Catecholamines can cause hypertension by increasing heart rate and cardiac output or by peripheral vasoconstriction.Aim of study: The value of plasma and urinary metanephrines and normetanephrines does not correlate with blood pressure in pheochromocytomas.Material and methods: The lot of study consist of 35 patients with isolated pheochromocytomas diagnosed between 1985 and 2005 in National Institute of Endocrinology C.I.Parhon Bu...

Introduction: The new tool FRAX indicated risk of fracture, using or not DXA which is the golden standard for osteoporosis diagnosis.Aim: We analyzed the lumbar DXA correlations with 10-year fragility fracture risk probability.Material and method: A cross sectional study in postmenopausal women was designed. They were osteoporosis free at baseline; none of them has previously been treated for osteoporosis. The anamnesis, the anthro...

Introduction: We evaluated the prevalence of metabolic and cardiovascular complications in a Romanian population with adrenal incidentalomas in comparison with an age-matched control group, evaluated in our clinic.Patients and methods: After excluding patients with overt functioning adrenal tumors, subclinical pheochromocytomas, malignant tumors, myelolipomas, data were retrieved from the files of 190 patients with adrenal incidentalomas ≥1 cm and ...