Endocrine Abstracts

Introduction: Even the differentiated thyroid neoplasm have good prognostic, there are some particular cases that become very aggressive in short time, with poor management.Aim: We report a female case diagnosed with invasive papillary thyroid carcinoma.Case report: Seventy-three-year old female was diagnosed at age of 71 with a right lobe thyroid nodule (of almost 6 cm). At that moment the computed tomography (CT) of the cervical ...

Introduction: Hashimoto’s Thyroiditis is a part of the spectrum of thyroid autoimmune diseases. Even the proper diagnosis is obtained by pathological exam; usually the detection of high serum antithyroid antibodies is enough to diagnose the disorder. It also represents the most frequent cause of hypothyroidism in non-iodine deficient areas. Nevertheless the presence of the antithyroid antibodies does not always correlates with thyroid dysfunction.Ai...

Introduction: The Gasser Ganglion is a large semi lunar-shaped ganglion of the trigeminal nerve. It contains the cells of origin of the most sensory fibers of the fifth cranial nerve.Aim: Our purpose is to describe a case where Gasser ganglion has an anatomic variant (near the sella turcica), mimicking a hypophyseal tumor.Case presentation: Of 17 years female patient has a history of bradispaniomenorrhea (menses at 30–50 days)...

Introduction: Incidentaloma is a randomly discovered tumor with no apparent secretor activity. The term is mainly used for hypophysis and adrenals. There are relatively few situations where a patient has more than one such mass.Aim: To present the case of a patient with three tumors: a pituitary mass and bilateral adrenal masses, with clinical manifestations of Cushing’s syndrome.Case report: A 37-year-old female patient who h...

Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...

Background: End stage renal disease is usually associated with high serum parathyroid hormone (PTH) and increased bone turnover. The aim of our study was to correlate serum PTH with serum markers of bone turnover in patients with end stage renal disease (ESRD).Methods: We measured serum PTH, osteocalcin, procollagen type 1 n-terminal propeptide (P1NP) and beta-crosslaps in 64 (32 men) consecutive pacients, median (25, 75 percentile) age 61 (49.5, 65.5) y...

Pituitary apoplexy is a rare syndrome due to a clinically overt hemorrhagic infarction, described in 2–7% of pituitary adenomas. A subclinical usually asymptomatic pituitary hemorrhage and/or infarction may be detected on routine imaging or during histopathological examination in 25–28% of patients with pituitary adenomas.Aim: We compared the clinical features and evolution of 166 patients with subclinical pituitary apoplexy (SPA) and 46 patien...

Background: Growth hormone, age, sex, genetics or nutrition status play an important role in insuline-like growth factor 1 (IGF-1) liver production and serum levels. Currently, there is no IGF-I reference range for Romanian population.Aim: To define sex- and age-adjusted reference values for serum IGF-I measured by an automated chemiluminescence immunoassay in adult Romanian population of healthy subjects.Methods: The study include...

IntroductionOncocytic neoplasms arising in adrenal tissue are extremely rare with nearly 150 cases being reported in literature. They are mostly nonfunctioning benign tumors, incidentally discovered, but 20% of them demonstrate elements of malignancy and up to 30% appear to affect hormone production.Case reportA 35 years old female with primary amenorrhea, diagnosed with Congenital Adrenal Hyperplasia due to ...

IntroductionProlactinomas are the most common hormone-secreting pituitary tumours encountered in the clinic. They are usually treated with dopamine agonists (DA): bromocriptine (BRC) and cabergoline (CAB), which are highly effective in the majority of cases. DA resistance is the failure to achieve normal levels of prolactin and, or reduction of the adenoma with at least 50%.Aimto assess the prevalence of the ...