Endocrine Abstracts

Introduction: Sorafenib, an orphan medication, is an oral protein kinase inhibitor, used in the treatment of hepatic, advanced renal and breast cancer, or metastatic iodine-refractary thyroid cancer. The drug also inhibits angiogenesis, and VEGF, having a dual effect on the tumor cells as well as on the tumor vasculature.Aim: We present a case with hyperthyroidism, as adverse effect of the therapy with sorafenib, but with no markers of thyroid autoimmuni...

Introduction: Pituitary adenomas (PAs) are rare in childhood and the transition period, can result from AIP/MEN1 mutations, are difficult to manage and severely impair quality-of-life.Aim: To describe the clinical and genetic characteristics of patients with PA onset before 21 years old.Patients and methods: Retrospective study (1980–2015). Clinical, imaging and hormonal data, AIP/MEN1 sequencing.<p class...

Background: Multiple endocrine neoplasms (MEN) are a rare hereditary syndrome, caused by an autosomal dominant mutation due to germline mutation in the rearranged during transfection (RET) proto-oncogene. According to the new WHO guidelines, MEN type 2 (formerly known as MEN 2A) is characterised by medullary thyroid cancer (MTC), paragangliomas, primary hyperparathyroidism (PHP) and cutaneous lichen amyloidosis.Objectives: To present the clinical and par...

Background: Subacute thyroiditis, autoimmune thyroiditis and an atypical form of thyroiditis due to primary injury of the thyroid gland by SARS Cov2 itself are complications of COVID-19. Angiotensin-converting enzyme 2 is also expressed in the thyroid gland. On the other hand, both untreated thyrotoxicosis and COVID-19 affects heart, generating cardiac complications.Case report: A 36-year-old woman resident in an iodine sufficient area, heavy smoker, pre...

Introduction: McCune-Albright syndrome is a rare, heterogenous disorder, consisting of at least two of the following three features: polyostotic fibrous dysplasia, café-au-lait skin pigmentation and autonomous endocrine hyperfunction. We present the case of a patient with an atypical presentation of McCune Albright syndrome (MAS) and severe fibrous dysplasia lesions.Case report: An 18-year-old girl diagnosed with MAS (at the age of four) was referre...

Context: The current pandemic showed a great handling of the resources and research in order to find not only a way to cure but also to prevent and improve the course of the Covid-19 infection. Optimal vitamin D (VD) levels and treatment was seen as a potential aid due, in principal, to its immunomodulatory effect. The ACE-2 receptor is the key the virus uses for entering the body, but its location is not restricted to the lungs, it’s also found in the adrenal cortex. At ...

Introduction: Acromegaly is a rare, chronic endocrinopathy, that results from persistent hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor 1 (IGF1). It is well known that GH excess has multisystemic effects throughout the body, but its interaction with the immune system has only been suggested in the last few decades. This prompted us to explore the frequency of autoimmune disorders in a retrospective acromegaly cohort....

Background: Dopamine agonists (DAs) were associated with valvular dysfunction in patients with Parkinson’s disease due to their fibrotic effect through the serotoninergic receptor. It is more difficult to prove the same effects in patients with prolactinoma due to the lower doses, variable doses and the longer follow-up period. Aim: To assess echocardiographic features in patients with prolactinoma under DA treatment.Methods: ...

Introduction: We describe the case of a 68-year-old patient, having two MEN1-associated tumors that are not part of the classical triad, with a penetrance of only 40%, and 2%, according to the medical literature. Furthermore, she developed a persistent hyperkalemia after the unilateral adrenalectomy, which is rare and often missed.Case report: In 2011, following a non-specific symptomatology (dry cough, fatigue), a bilobectomy was performed (medium and r...

Background: In patients with acromegaly, mortality depends most on achievement of control of GH/IGF1 levels. However, some of the complications of acromegaly still develop, despite successful control of disease. The aim of the study is to correlate mortality and morbidity with cumulative GH exposure in these patients compared to last GH/IGF1 level.Methods: We studied retrospectively 336 patients with acromegaly consecutively evaluated at least twice duri...