Endocrine Abstracts

Background: Cushing’s disease is characterized by chronic ACTH hypersecretion, leading to hyperplasia of the adrenal zonae reticularis and fasciculata and, therefore, increased secretion of cortisol, androgens and DOC. Cushing’s disease is the most common form of Cushing’s syndrome, being responsible for approximately 80% of reported cases.Aim: To evaluate the curability rate of Cushing’s disease 1 year postoperatively.<p clas...

Fine-needle aspiration (FNA) is the best available technique for preoperative diagnosis of malignancy in thyroid nodules. Although its efficiency has been well described, the learning curve is underreported. We aimed to describe the learning curve of a new FNA facility (endocrinologist/pathologist) in a university based hospital.Methods: In February 2018 a new FNA facility was formed in our hospital comprising an endocrinologist with high experience in t...

Introduction: Histiocytosis X is a rare disease involving clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Its manifestations range from isolated bone lesions to multisystem disease. Seen mostly in children, multifocal histiocytosis may involve in 50% of cases the pituitary stalk, leading to diabetes insipidus and usually permanent pituitary deficiencies. We present an adult patient with a com...

Background: Hypothyroidism is a frequent side effect of external radiotherapy of the cervical region for head and neck cancer. Up to 33% of irradiated patients developed primary hypothyroidism within 2 years after radiation therapy. The risk of hypothyroidism increases with radiation dose.Patients and methods: Four patients (2M/2F), aged 53.3±13.9 years, resident both in iodine sufficient (n=2) and iodine deficient areas (n=2), wer...

Aim/objectives: To investigate relationships between thyroid function, antithyroperoxydase antibodies (ATPO), antithyroglobuline antibodies (ATG) and correlations with echographic pattern in Hashimoto thyroiditis and related diseases.Materials and methods: Diagnosis: i) ATPO >34 μ/ml=Hashimoto thyroiditis (HT); ii) ATPO=normal with high ATG=thyroiditis with only hyper-ATG (T-ATG). Thyroid function: TSH. Echographic patterns=10 (Peretianu, this C...

Bone mass density and beta cross laps have been recognized as valid tests for the diagnostic and treatment control, as well as fracture prediction for osteoporotic patients. Statin treatment has been reported to be associated with a reduced risk fracture in these patients also. However, no studies, as of our knowledge, have tried to see if adding the lipid profile to the analysis of body mass density would improve the statistical power of prediction for any of the afore mentio...

Background: In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anesthetic management differs function of etiology (primary vs secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy).Aim: To evaluate peri-operative management in parathyroidectomy for hyperparathyroidism of various etiologies, in a tertiary center.Patients and methods: Two ...

Introduction: Hyperthyroidism-associated myocardial infarction with normal epicardial coronary arteries on angiogram is seldom reported.Case report: A 61-year-old Caucasian man, resident in an iodine sufficient area, presented with chest pain in the emergency unit. ECG revealed inferolateral myocardial infarction with ST-segment elevation. Soon after admission, the patients developed collapse due to primary ventricular fibrillation, requiring defibrillat...

Background and Aim: Clinical and experimental studies demonstrated that total insulin-like growth factor 1 (IGF-1) levels are reduced in the patients with poorly controlled diabetes. The aim of the present study was to investigate the levels of IGF-1 in patients with acute metabolic acidosis.Materials and Methods: 17 patients with thype 1 diabetes and moderate or severe metabolic acidosis were recruited for this study. Serum levels of IGF-1 were determin...

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 10 years ago.Material/method: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) Description – eight ETP: pattern 0 – lack of thyroid, 1 – hypoechogenous pseudonodular; 2 – hypoecogen homogenous; 3 – micronodular hypoechogenous; 4 – macro (> 10 mm; ±micro) nodular;...