Endocrine Abstracts

Background and aims: Clinical studies demonstrated that hypothyroidism can be a cause of hypercreatininemia. The aims of the present study were to investigate the prevalence of hypercreatininemia in patients with primary hypothyroidism.Materials and methods: We retrospectively studied serum creatinine levels in 54 patients with primary iatrogenic hypothyroidism (iatrogenic hypothyroidism result seccondary to radioactive iodine therapy and surgery). Resul...

Objectives: To investigate how the immune associations (IA) may have significance for diagnosis or therapy in thyroiditis.Material and method: Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT) =1092, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) =61, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis) =5, D. idiopathic myxedema (hypothyroidism, no A, B,C) =70; E. control...

Aim and objectives: To investigate the rapport between the level of thyroid function, through blood level of TSH, both at onset, and in evolution and the level of antithyroperoxydase antibodies (ATPO) and antithyroglobuline antibodies (ATG) in Hashimoto thyroiditis and related diseases.Material and method: Diagnosis: a. ATPO >34 μ/ml = Hashimoto thyroiditis (HT); b. ATPO=normal with high ATG = thyroiditis with only hyper-ATG (T-ATG); c. hypothyr...

Aim: Analyzing the evolution of thyroid function in thyroiditis and related disease during 1–15 years.Materials and methods: A) Diagnostic: Hashimoto thyroiditis (HT): i) antithyroperoxydase antibodies (ATPO) cut-off 34. ii) If ATPO=normal (N), was considered thyroiditis with only antithyroglobuline antibodies (T-ATG); iii) idiopathic mixedema (IM): hypothyroidism, no ATPO, no ATG, no TRAB.B) Patients: i) HT: 1092; T-ATG: 61; ...

Aim, Objectives: Conceptualizing new data related to type and level of autoantibodies in thyroiditis Hashimoto, Graves-Basedow disease and releated conditions.Material: ###1. Adoption the integrative concepts of immune network (Nobel Prize, 1984) for immune thyroid diseases. 2. Searching on “www.ncbi.nlm.nih.gov/pubmed” for papers with keywords: thyroid autoantibody, thyroiditis (~2500 papers). 4. New (auto)-antibodies (and antigens/epitopes) f...

Study: Retrospective, cohort.Material and methods: A. Hashimoto thyroiditis (HT) diagnosis: i) antithyroperoxydase antibodies (ATPO) criteria; cut-off >34 IU/ml. ii) If ATPO=normal (N), HT was considered only antithyroglobuline antibodies (ATG) were >50 IU/ml (↑) and ultrasound was pattern 1 (pseudonodular, intense hypoechogenic, inhomogeneous – Peretianu, Endocrine Abstracts, 2007, 14, P340; 2008, 16, P772; 2009, 20, P79).<p class...

Premises: Numerous recent medical journals and communications insist on the high prevalence of Hashimoto’s thyroiditis (HT) associated with breast cancer in women (see www.ncbi.nlm.nih.gov/ key words: breast cancer, thyroiditis, #91).Objective: We proposed to present data from our casuistry related to HT (over 2000 patients and control, including men), observed during last 10 years.Mat...

Background and aims: Incretin mimetics are a new class of pharmacological agents with antihyperglycemic actions that mimic the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1. The thyroid gland exhibit a strong GLP-1 receptor expression in rodents but only low receptor levels in humans. GLP-1 receptors activation stimulates calcitonin secretion and promotes the development of C cell hyperplasia and medullary thyroid cancer in rodents....

Background and aims: Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). The therapy with antiretroviral drugs is associated with increasing reports of metabolic abnormalities such as body fat abnormalities, impaired glucose metabolism and insulin resistance, dyslipidemia. We investigated the prevalence of diabetes mellitus in patients with AIDS in treatment with antiretroviral drugs.<p class="...

Among hypertensive population, almost 10% have primary hyperaldosteronism. In these cases, most abnormalities are related to hypokaliemia with progressive or acute onset of the symptoms.We present the case of 34-year-old male patient, without significant pathological history, with a sudden neurological episode, dominated by tetraplegia and mild elevated blood pressure. Extremely low values of serum potassium are found. Diabetes mellitus is also discovere...