Endocrine Abstracts

The aim of por in-vitro studies was to examine the involvement of transcription factor NF-kB (p50/p50, p65/p65) and FSH in control of porcine ovarian granulosa cells functions and the possible role of dimers p50/p50, p65/p65 in mediating FSH actions on these cells. Monolayer of primary granulosa cells was transfected with plasmids encoding human p50 cDNA and p65 cDNA, and cultured with or without addition of FSH (0, 1, 10 or 100 ng/ml). The accumulation of proteins p50 and p65...

The aim of our study was to examine the role of mTOR-dependent intracellular signalling pathway in tle control of ovarian functions. For this purpose we have examine the effect of two mTOR inhibitors (resveratrol and rapamycin) on the release of hormones by cultured rabbit ovarian fragments. The secretion of hormones (progesterone, testosterone, estradiol and prolactin) by fragments of rabbit ovaries cultured during 48 h with and without addition of resveratrol or rapamycine (...

Purpose of work: Research influence of insulin therapy in the form of combine therapy with analogue of prolonged insulin – glargin and per oral anti diabetes treatment with (glibenclamide) on dynamics of risk of development of coronary (CHD) heart disease and death rate from cardiovascular disease (CVD) at diabetes mellitus type 2 (DM 2).Materials and methods: During the study was researched dynamic of risk of development CHD and death rate from CVD...

A 43-year-old woman presented acutely with Graves disease and hyperthyroidism. She had thyroid eye disease and a large diffuse goitre with pressure symptoms. She reported hearing a bruit herself without a stethoscope. She was tachycardic, with capillary nail fold pulsation and a positive Pemberton’s sign. Initial T4 was 78.6, TSH not detected.Betablockers to control the patients tachycardia were contraindicated due to a history of asthma,...

The aim of the present study was to examine the role of steroid hormones in control of growth and obesity. We have measured plasma level of progesterone (P4), testosteron (T) and estradiol (E2) in 301 adolescent girls at different stages of their ovarian cycle, and compared they with standard morphometric indexes of their growth and obesity – body height, body mass, abdomen and hip circumstances and waist to hip ratio (WHR). The ovarian cycle-depende...

Background: Manifestation of early age adiposity raises complicated forms of obesity and risks for concomitant diseases development.Objective: To detect obesogenic risk factors in preschool children screening study.Material and methods: Of 1008 children from 8 Minsk kindergartens were screened. Anthropometrical parameters, systolic and diastolic blood pressure (SBP and DBP) were measured. Body mass index (BMI) standardized for age ...

Objective: The majority of circulating testosterone is bound to sex hormone-binding globulin (SHBG), but also to albumin and cortisol-binding globulin. The remaining part is free-circulating testosterone unattached to serum proteins, which represents the active form of the hormone. A common measurement of the free testosterone is the calculated free testosterone index (FTI)=100*(total testosterone/SHBG). Testosterone is the principal male sex hormone and is involved in the reg...

The aim of the study is to compare efficacy of RAI in patients with Graves disease using different methods calculation of optimum therapeutic activity.Methods: About 60 patients (50 women, 10 men, mean age 44.8±11.8 years) with Graves decease were treated with RAI. The treatment with ATD was cancel 10 days before RAI to restore the iodine intake by thyroid gland. Therapeutic activity was determent individually 1) with applied the special formula in ...

Background and aims: The aim of this study was to assess the effect of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) on the heart rate variability (HRV), dynamics of such biochemical parameters in patients (pts) with Type 2 DM and cardiovascular aunonomic neuropathy (CAN).Materials and methods: Forty-nine pts with CAN (54±5 years) were allocated in two groups. Pts of group A (n=17) were receiving capsules of fish oil every day (‘...

Background and aims: The aim of this study was to assess the effects of simvastatin (SIM), eicosapentaenoic (EPA), docosahexaenoic acid (DHA) on dynamics of such biochemical parameters in type 2 diabetic patients with cardiomyopathy (DCMP).Materials and methods: Twenty-five patients with DM and DCMP received SIM 20 mg tid (group A); B (n=37) – capsules of fish oil (‘Epadol’: 2.0 g EPA, 2.0 g DHA and 0.1% α-tocopherol acetate), ...