Endocrine Abstracts

Objective: The LH and chorionic gonadotropin (CG) are essential for reproduction and male sexual development. While LH induces tesosterone production, CG is essential for the establishment of pregnancy. In the New World Monkeys (NWM) the initial duplication of the ancestral LH-beta subunit (LHB) gene, which gave rise to the novel CG-beta subunit (CGB) gene, was followed by a genomic rearrangement event, leading to CGB expression in pituitary and placenta, whereas LHB became a ...

Aim: To pay attention to the so rare symptom of diffuse toxic goiter (DTG) as fever.Materials and methods: We report about 5 patients (all females, aged 18–38, mean – 31). Before, all patients were examined for fever of unknown origin of long duration. After the others reasons of the febrile body temperature were excluded, DTG was diagnosed. DTG was confirmed by the results of the clinical, hormonal and immunological investigations (T- and B-ce...

In 24 years old woman in March 2007 was diagnosed acromegaly (somatoprolactinoma) an active phase, hyperprolactinemia. Manifestations: rugged features, amenorrhea, galactorrhea, fasting GH – 144 ng/ml (N<10 ng/ml), IGF-1 – 586 ng/ml (N 48–450 ng/ml), PRL – 6726 mU/l (N 40–530 mU/l). According to pituitary MRT a tumor volume was 14.4 cm3, with supra- and infrasella growth. She was operated in May 2007: transnal transs...

A 60-year-old gentleman of previously good health presented with a 6 months history of resistant hypertension, newly diagnosed Diabetes Mellitus, worsening obesity and proximal muscle weakness. Clinical examination revealed a buffalo hump, truncal obesity, paper thin skin with bruising and proximal muscle wasting. His biochemistry showed elevated midnight cortisol levels, no suppression of cortisol post high dose dexamethasone and an undetectable ACTH. Accompanying abnormaliti...

Background and aims: The aim of this study was to assess the effects of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) on the heart rate variability (HRV), some biochemical parameters in patients (pts) with Type 2 diabetes mellitus and cardiovascular aunonomic neuropathy (CAN).Materials and methods: 39 pts with CAN (54±5 yrs) were allocated in two groups: A (n=26) were receiving capsules of fish oil every day (2.0 g EPA, 2.0 g DHA and ...

Background and aims: The present study has examined the effect of α-lipoic acid (ALA) and nicotinamide (NA) on the heart rate variability (HRV), superoxide dismutase (SOD), gluthation peroxidase (GPO), catalase activities, reduced gluthatione (GSH), malondialdegide (MDA) contents in the RBCs’ in Type 2 diabetic patients (T2DM) with cardiovascular autonomic neuropathy (CAN).Materials and methods: 59 patients with T2DM and CAN (59.3±7.9 year...

Background and Aims: The aim of this study was to evaluate the effects of pioglitazone (PGZ) and metformin (MET) plus Hypocaloric Diet (HD) in young patients with obesity and impaired oral glucose-tolerance test (75 g glucose).Materials and methods: 49 patients (17.1±1.2 yrs) were allocated in groups: A (n=14) received PGZ 30 mg tid plus HD, B (n=12) - MET 1000 mg tid plus HD, C - PGZ 30 mg plus MET 1000 mg plus HD (n=11), D (<i...

Vascular calcification is a regulated process with similarities to osteogenesis, however, the precise mechanism underlying this process is poorly understood. Pericytes are pluripotential microvascular cells which have been shown to differentiate along an osteogenic lineage. Glucocorticoids are widely prescribed drugs but have adverse side-effects including both vascular lesion formation and bone loss. The mechanism underpinning the contrasting effects of dexamethasone (dex) on...

Context: Hyperglycemia is common among patients with and without diabetes mellitus (DM) hospitalized for infectious diseases. The long-term outcomes of hyperglycemia have not been adequately studied in this population.Objective: Examine the prognostic implications of hyperglycemia and the importance of glycemic control in patients with and without DM during hospitalization for infectious diseases.Methods: Historical prospectively c...

Interferon alfa-2a was discontinued in June 2020. Here we present a case of an unfortunate patient for whom this change has dramatically impacted the course of her illness. A 64-year-old woman initially presented in 2007 with refractory hypertension and was found to have a phaeochromocytoma which was resected. Metastatic recurrence of her disease in the liver and vertebrae was confirmed by CT/MRI in 2014 following rising catecholamines on monitoring. Her MIBG scan in early 201...