Endocrine Abstracts

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26&#150...

Background: An increased incidence of thyroid cancer among young population of contaminated territories of Russia after Chernobyl accident made very important morphological verification of diagnosis. Many epidemiological and molecular studies of post-Chernobyl thyroid cancer conducted by various research teams required an independent review of tumour histology. The International Pathology Panel formed consensus diagnosis for each case of post-Chernobyl thyroid tumours and prop...

Objectives: Many paediatric diabetes units in the UK have introduced 24 h telephone support to encourage self-management to reduce Emergency Department (ED) attendances and admissions. The UK national audit collects information on acute paediatric diabetic admissions; but there is no data available on ED attendances in this group. We undertook a retrospective audit of ED attendances as part of a baseline service evaluation of our newly introduced 24 h support service.<p cl...

Neurons in the hypothalamus play central roles in physiology and behavior, and their loss or dysfunction cause common human diseases such as obesity and the sleep disorder narcolepsy. Efforts to study these diseases have been hindered by the inaccessibility of human hypothalamic neurons. I developed a robust method to generate hypothalamic neurons from human embryonic and induced pluripotent stem cells. These stem cell-derived hypothalamic neurons include the AGRP and POMC neu...

Objectives: 1) When and how to investigate rarer causes of short stature. 2) Evidence for interventions to improve growth in metaphyseal chondrodysplasia, Schmid-type (MCDS).Background: The incidence of skeletal dysplasia is one in 5000, however individually these conditions are rare and prognosis unclear. There is genotypic and phenotypic heterogeneity and no current consensus on classification, which may include clinical, radiographic, molecular or his...

Introduction: Pituitary apoplexy is the rare case of panhypopituitarism. We are presenting a clinical case of pituitary apoplexy in a previously healthy 37-year-old woman.Case report: A 37-year-old woman developed amenorrhea in August 2011. She did not visit a doctor in that time. In December 2011 she suddenly felt severe headache, symptoms of polyuria and polydipsia and temperature of 39 °C. Laboratory results revealed an increased erythrocyte sedi...

Background: Papillary thyroid carcinoma (PTC) is a well differentiated malignant tumour that usually has a good prognosis in vast majority of patients after thyroidectomy, suppressive hormonal, and radioiodine treatment. However 5–10% of PTC cases can develop local relapse and distant metastases.Purpose of study: To make a comparative morphological analysis of PTC in two groups of patients: i) with and ii) without local relapse (regional metastases)...

Introduction: Resistance to thyroid hormone (RTH) is a rare disorder characterized by reduced tissues’s responsiveness to thyroid hormones (TH). Usually patients with RTH have not clinical signs except goiter. We describe a 70-years old woman with RTH and autoimmune thyroiditis simultaneously.Case report: Woman 70-years old was hospitalized in our department on August 2011 with suspicious of Thyrotropinoma because of high levels of TSH and fT4<...

Purpose of the study: Research dynamic of parameters of mineral metabolism, during 12 months therapy with Strontium ranelate (in dose – 2 g/day) at women with postmenopausal osteoporosis and diabetes type 2 (D2).Materials and methods: Forty-two women (age 65.9±3.2 years) in postmenopausal period with verified DM2 (DM2 longer from 1 to 12 years, all patients have standard on per oral therapy with ant diabetes drag – gliclazide, metformin or...

Improvements in real-time intravital imaging techniques and two-photon microscopy make it now possible to visualize the complex tumor microenvironment in vivo, over time and deeply within intact tissues. Using dynamic imaging, we addressed central aspects of tumor progression, including dynamic interactions of invading tumor cells with the tumor microenvironment and the local regulation of tumor infiltrating immune cells in eradicating tumor cells.<p class="abstext"...