Endocrine Abstracts

Introduction: Diabetic ketoacidosis (DKA) can be easily confirmed with the triad of hyperglycaemia, metabolic acidosis and ketonaemia/ketonuria when suspected. DKA presenting as acute abdomen sometimes is well known, but not vice versa. We describe a rare presentation of acute abdomen with stress hyperglycaemia masquerading as DKA.Case Report: 2 year old boy presented with abdominal pain for 8 hours, vomiting & lethargy and tachypnoea & tachycard...

IntroductionIn primary hyperparathyroidism (PHPT) the chronic overproduction of parathormone (PTH) is mostly due to a solitary adenoma.AimThe aim of our study was to examine the relationship between calcium-phosphate metabolism and the volume of the parathyroid adenoma (PTA) in patients with PHPT.Material and methodsThe study included 195 patients with biochemical...

Bile acids (BA) regulate glucose and lipid metabolism, provide bile flow, increase lipase activity by 10–15 times. With the development of inflammation, violations occur in the membrane proteins of glucose transporters.AimDetermine the total pool of bile acids in NAFLD with diabetes mellitus (DM) and impaired glucose tolerance (IGT). Determine the content of inflammation markers lipoprotein-associated phospholipase (Lp-PLA2), ...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes andnon-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates th...

One of the most common environmental endocrine disruptor is bisphenol A (BPA), which mimics estrogen effects. Even at low expositional dose, BPA is capable of transferring across the human placenta in active unconjugated form. The purpose of this work was to investigate the long-term effects of low dose BPA introduction to rats during the critical period of sexual differentiation of the brain on the reproductive system and the behavior of F1 offspring. Wistar dams were exposed...

IntroductionThyrotropin-receptor antibodies (TRAb) play a key role in the pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) and are important for the diagnosis of both diseases. Elevated levels of immunoglobulin E (IgE) and antinuclear antibodies (ANA) were also found in GD patients. Smoking is a risk factor for GD and GO development and GO progression. We aimed to assess the associations between TRAb, IgE and ANA, and the prese...

Purpose of researchTo determine the level of insulin content, the content of nitric oxide metabolites, Malondialdehyde, the activity of lipoprotein-associated phospholipase A2 (FLA2), in the blood serum of patients with NFLD with type II D and impaired glucose tolerance.Material and methodsThe study included 74 patients with non-alcoholic fatty liver disease. 30 of them have diabetes of the second type, and 3...

Background: Mutation in the CYP24A1 gene can have variable phenotypes including infantile hypercalcemia and adult-onset hypercalcemia, hypercalciuria, nephrocalcinosis, or nephrolithiasis. CYP24A1 gene mutation is a rare but important cause of PTH-independent hypercalcemia.Case Presentation: We describe a case of a 67-year-old gentleman who presented with lethargy, fatigue and weight loss. He was found to have PTH-indepe...

A 58 year-old man presented with backache and was found to have T10-T12 vertebral fractures on spinal-MRI. He was diagnosed with osteoporosis on a DEXA-scan (lumbar-spine T-score-2.6) and was treated with Alendronate and Cholecalciferol at a neighboring hospital. He was referred to the endocrine bone-clinic for a second opinion regarding his osteoporosis. He had a history of multiple small bone fractures and Brucellosis that required a 2-month bed-rest. His family history incl...

Background: The registry is the main source of information about patients with acromegaly for assessing the quality of medical care, effectiveness of treatment, determining the compliance of real clinical practice with existing standards and patient management protocols.Aims: To analyze the epidemiological, demographic and clinical characteristics of acromegaly in the Russian Federation and the effectiveness of various treatment methods.<p class="abs...