Endocrine Abstracts

Adrenocortical carcinoma is a rare tumor characterized aggressive growth and poor prognosis. This tumor requires the complex way of treatment, where basic method is surgery.The aim of this study was to evaluate the long-term outcome and role of surgery in patients with adrenocortical carcinoma.Methods: From 1998 to 2007, 44 patients were operated for adrenocortical carcinoma (14 cortisol-secreting tumors, 1 virilizing tumor and 29 ...

Maternal stress modifies fetal programming of neuroendocrine development and behavior. These effects are mediated by maternal and fetal corticosteroids and opioids. We evaluated an ability of pharmacological prevention of long-term behavioral and hypothalamic–pituitary–adrenal (HPA) disorders in adult rat offspring induced by daily 1 h maternal immobilization during the last gestational week. Dexamethasone (Dex; 0.1 mg/kg per day) or naltrexone (Ntx; 10 mg/kg per day...

Introduction: Up to 40% of cases with endocrinologically and surgically proven Cushing’s disease (CD) are MRI-negative1. With intraoperative transsphenoidal ultrasound 72% of microadenomas in CD were identified as hyperechogenic structure2. We report on the first 9 cases with intraoperative use of direct contact high-frequency ultrasound (hf-us) in patients with CD.Patients: All 9 cases (all female, age 31–71 years) reveal...

The effect of mTOR inhibitors on pituitary tumors is unknown. Akt overexpression was demonstrated in pituitary adenomas, which may render them sensitive to the antiproliferative effects of these drugs.To evaluate the in vitro effects of mTOR inhibitor rapamycin, and its orally-bioavailable analog RAD001 on pituitary cells, GH3 cells, a mammosomatotroph rat pituitary tumor cell line, and human GH-secreting and non-functioning pituitary adenoma (NFP...

Chemosensory cues from receptive females produce the activation of the pituitary–testicular axis and facilitate a complex display of sexual behavior in male mice. Testosterone output in response to a receptive female and the pattern of sexual behaviour were investigated in male mice (n=190) of three inbred strains BALB/cLac, CBA/Lac and PT at puberty (45 days of age) and in adulthood (90 days). Sexually naive pubertal or adult male was exposed for 10 min to a recep...

Aim: To assess the accuracy of the TBSRTC in verification of thyroid carcinoma in the region of Moscow county.Material and methods: A retrospective study of data from electronic medical notes of 1,675 patients who underwent fine needle aspiration biopsy of nodular thyroid glands in 2016. The cytological conclusion was evaluated in accordance with the TBSRTC. In cases of surgical treatment (thyroidectomy or hemithyroidectomy) the cytological diagnosis was...

Molecular basis of the bone disorders in patients with acromegaly are largely unknown.Objective: To investigate microRNAs (miRNA) expression profiles that regulate bone metabolism in plasma samples from patients with acromegaly.Materials and methods: Fasting plasma samples were taken from consecutive subjects with biochemically confirmed active acromegaly and healthy volunteers matched by age, sex and BMI. IGF1 was measured by an e...

The results of a survey of 209 patients with Diabetes mellitus type 2 (DM 2) and 94 patients with X-syndrome were analyzed. Non-alcoholic fatty liver disease (NAFLD) is verified in 91.9% of cases with DM 2 and 83.0% with X-syndrome. Predictors that significantly influenced the development of NAFLD in X-syndrome have been identified: age (b=0.07; Exp (b)=1.07(1.02÷1.14); P<0.02); body mass index (b=0.37, Exp(b)=1.45 (1.16÷1.81), P<0.001), tot...

Proinflammmatory cytokines including interferon gamma (IFNg) are known to be involved in the pathogenesis of diabetic nephropathy. The aim of this study was to assess serum level of IFNg and its clinical correlates in patients with type 2 diabetes and early CKD receiving different types of treatment. We investigated 64 patients with type 2 diabetes and CKD stages 1-3. Group 1 included 20 patients on insulin therapy. Group 2 included 44 patients on metformin or combined oral hy...

Introduction: Acromegaly is a rare chronic disease caused by growth hormone (GH) and insulin-like growth factor 1 type (IRF-1) excess. However, reaching biochemical control of the disease does not always guarantee the improvement of symptoms that play a significant role in the quality of life associated with human health (HRQoL), in particular, patients with acromegaly.Goal: To investigate the quality of life in patients with acromegaly in the Moscow reg...