Endocrine Abstracts

Introduction: Data on transsphenoidal surgery (TSS) and effect of somatostatin analog therapy (SSA) in acromegaly different among medical centers. We analyzed the data on TSS, SSA and their combination in acromegalic patients of Moscow region.Design: In this study 117 acromegalic patients (25 males and 92 females, 55.0 (IQR 44 – 62) years) were eligible for participation, of whom 34 were newly-diagnosed aromegaly (NA group) (macroadenoma (macro)- 80...

Introduction: The usual treatment for autonomously functioning benign thyroid nodules was surgery until the advent of new techniques such as radiofrequency ablation (RFA). This study aimed at estimating RFA efficacy of autonomously functioning benign thyroid nodules.Material and Methods: The analysis included the results of treatment of 108 patients with autonomously functioning benign tumors of the thyroid gland, received in the Samara Oncology Center. ...

Background: Subtyping of primary aldosteronism (PA) using imaging and adrenal vein sampling (AVS) can yield discordant results. Varying interpretation criteria in determining AVS lateralization may affect discordance rates.Methods: We identified 337 consecutive patients with PA who underwent AVS at a quaternary care centre between August 2006 and February 2018. Patient demographics, laboratory results, diagnostic imaging, AVS results, and pathology were ...

Background: Negative imaging in the work-up for unilateral (surgical) primary aldosteronism (PA) presents a diagnostic dilemma. Clinicians may assume bilateral disease and treat medically or may proceed to adrenal vein sampling (AVS) to try to localize a unilateral source of aldosterone secretion. However, AVS is not without cost, risk, and limited access. We describe AVS results among imaging-negative PA patients.Methods: We identified 96 patients with ...

We present the case of a 35-year-old woman who was well until pregnancy 4y previously in Israel. Her antenatal course was uncomplicated. She breastfed postpartum and a few months into this she experienced acute back pain on reaching for a nappy. MRI demonstrated six vertebral fractures. DEXA scan confirmed osteoporosis (lumbar T-score −4.3, hip T-score −3.3). She received a single dose of denosumab. She moved to the UK 2y later and was referred to our Endocrine Bon...

A 85-year-old man presented with a 2-week history of malaise, confusion and agitation and 4 weeks of polydipsia and polyuria, with water intake of 6 l/day. His past medical history included hypertension, congestive cardiac failure, and chronic kidney disease. On examination he was hypervolaemic. Initial investigations were as follows: serum sodium 115 mmol/l, potassium 4.6 mmol/l, urea 8.1 mmol/l (2.5–7.8), creatinine 138 μmol/l (66–112), serum osmolality 245 mO...

Studying the effect of deuterium depleted water (DDW) on isotope (D/H) composition and condition of an antioxidant-prooxidant plasma and lyophilized tissues of internal organs (liver, kidney) balance appropriate indicators in rats were compared: in group 1 (n=15) consumed mineralized water (150 ppm), which by a single intraperitoneal injection of alloxan (at a dose of 17 mg/100 g body weight) was established experimental model of diabetes; group 2 (n=15) cons...

Increasing evidence indicates chronic stress plays an important role in a variety of health problems such as the development of autoimmune disease, and the results from mice studies suggest that the central endocannabinoid (eCB) system regulates endocrine and neuronal responses to stress. However, it is unclear how the eCB system responds to chronic stress in healthy humans. A 520-day isolation-and-confinement study simulating an interplanetary spaceflight mission to Mars prov...

Background: Patients with Cushing’s syndrome (CS) have a lot of complications due to chronic exposure of cortisol.Aim: To reveal specific changes of cardiovascular system in patients with CS.Material and methods: i) Six patients with CS (five females, one male, 47.1±1.5 years old), duration of CS 3.4±1.2 years, ii) 19 healthy patients (48.1±3.0 years old), and iii) ten patients with ischemic heart disease (IHD) ...

We analysed BMI of 270 female patients: 148 with hyperprolactinaemia (non-tumoural hyperprolactinaemia, n=46; microadenomas, n=56; and macroadenomas, n=46), 55 with isolated central hypogonadism, 67 with hypopituitarism. Additionally, 53 healthy women of reproductive age and 51 postmenopausal women were examined. In patients with hyperprolactinaemia median prolactin levels were 1547 (1124; 2185), 1490 (1050; 2280), and 3100 (1790; 18840) mE/l, accord...