Endocrine Abstracts

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

Background: One of the basic genetic factors that impact on development of diabetic nephropathy is enhanced expression of vascular endothelial growth factor (VEGF).Objective: To study association between VEGF polymorphism +405 G/C and early stage of chronic kidney disease (CKD) in patients with impaired glycemic states.Materials and methods: 73 included patients were divided into three groups: group 1–26 patients with prediabe...

Background: Klinefelter syndrome (KS) is the most frequent genetic cause of male infertility. Individuals share the endocrine hallmark of hypergonadotropic hypogonadism, displaying high gonadotropin levels due to deficient testicular function. A single-nucleotide polymorphism (SNP) located within the FSHB promoter region (−211G>T, rs10835638) was recently shown to be associated with reduced serum FSH levels and other reproductive parameters in men. The objec...

Objective: To provide a latent class regression model predictive of surgical outcome in patients with non-functioning macroadenomas (NFMA) of the pituitary gland.Patients and methods: Seventy-five patients with surgically treated NFMA of the pituitary gland were analyzed retrospectively. Thirty-two patients were male. Median age at the time of surgery was 58 years (range: 16–84 years). Median follow-up time was 90 months (range: 14–208 months)....

We investigated 49 patients with non-functioning pituitary macroadenomas: 11 males, 38 females, age 31–78 y.o. (median 61). Extrasellar tumor expansion was observed in 46 (93.9%) patients: suprasellar – 41 (83.7%), laterosellar 27 (55.1%), and infrasellar 18 (36.7%) patients; combined types of extrasellar expansion – 36 (73.5%) patients.Prolactin levels (PRL) varied from 115 to 1495 mU/l, hyperprolactinemia was found in 27 (55.1%) patients...

Chronic heart failure (HF) is a major cause of morbidity and mortality in humans and domestic animals. HF is characterised by chronic inflammation and functional changes in non-cardiovascular tissues; obesity is also associated with low level chronic inflammation, with adipose tissue (AT) exhibiting infiltration of macrophages and alterations in fatty acid (FA) profiles. The aim of this project was to investigate expression of regulators of lipid metabolism and inflammation an...

Quercetin and resveratrol, powerful antioxidants and blockers of intracellular mTOR signalling system, are widely distributed in edible plants. Their action on ovarian cell functions and the interrelationships with gonadotropin are studied insufficiently. We examined the effect of FSH, quercetin, resveratrol and their combinations on proliferation and apoptosis of cultured porcine ovarian granulosa cells. Accumulation of marker of proliferation (PCNA) and marker of apoptosis (...

Introduction: Myxoedema coma is a rare complication of hypothyroidism. Although malnutrition is considered rare in developed countries, research has indicated that there are more than three million people in the UK suffering from or at risk of malnutrition. We present a case of myxoedema coma co-existing with malnutrition.Case report: A 51-year-old Caucasian female presented with acute confusion, peripheral oedema and a bilateral lower limb rash. On exam...

Insulin resistance and obesity are a global health problem and directly linked to macrophage-driven inflammation of the adipose tissue. Glucocorticoid therapy, used to treat inflammatory conditions, increases adiposity and insulin resistance. It is unknown however, whether anti-inflammatory actions of glucocorticoids at physiological levels can have beneficial effects on adipose tissue inflammation, potentially limiting insulin resistance. Using a macrophage specific deletion ...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates t...