Endocrine Abstracts

Purpose: To investigate the kinetics of adrenocorticotropin (ACTH) following oral metyrapone administration and describe differences between ACTH-deficient and non ACTH-deficient subjects.Methods: Patients from a tertiary endocrine center at a University Hospital in Munich, Germany, were tested. Metyrapone (Metopirone, HRA Pharma, France) was administered with a dosage of 40 mg/kg bodyweight at 0800 h. Consecutive levels of ACTH were determined at 0, 60,...

Introduction: Regardless of improvements in MRI, up to 20% of ACTH-secreting pituitary tumors are only identified at surgical exploration. The objective was to estimate whether there is any difference in blood vessels and the subsequent ability to uptake contrast agent in visualized micro-adenomas as compared to non-visualized on MRI ACTH-secreting pituitary tumors.Materials and methods: Retrospective evaluation of ACTH-positive pituitary tumors from pat...

Background: Type 2 diabetes (T2D) is a progressive disease. The gut microbiota has recently been identified as a new potential diabetes risk factor.Design: To investigate the gut microbiota composition in association with the dietary patterns in patients with different glucose tolerance we analyzed 92 patients: with normal glucose tolerance (n=48), prediabetes (n=24) and T2D (n=20). Metagenomic analysis was performed using 16Sr...

The aim: To establish unfavorable genetic polymorphisms on the development of comorbidity of DM2 and EH in Ukrainian population and to evaluate the effectiveness of α-lipoic acid appointment (α-LC) in complex therapy in patients with 3-4 crossed unfavorable genetic polymorphisms.The primary examination of 167 patients with DM2 in combination with EH showed that A/C and C/C genotypes of AGTR1, Pro/Pro genotype of PPARγ2, Arg/Arg ...

Introduction: Acromegaly is a chronic disorder caused by growth hormone (GH) hyperproduction which leads to significant morbidity and mortality primarily due to cardiovascular and respiratory complications. Pituitary adenoma is the main cause of GH’s hyperproduction. By current guidelines transsphenoidal surgery (TSS) is the first-line treatment in acromegaly patients.Aim: To evaluate the results of TSS in acromegaly patients 6 months after surgery....

Objective: Whether additional immunosuppressive drugs to standard treatment with thyreostatic drugs reduce the risk for relapse in Graves’ disease is not well understood. We performed a systematic review and meta-analysis to study the effects of immunosuppressive drugs on relapse rate and treatment effect of patients with hyperthyroidism due to Graves’ disease.Methods: We searched PubMed, EMBASE and Cochrane in July 2015 for randomized-controll...

The nodular goiter is the most prevalent thyroid disorder. Its prevalence increases with age and reaches over 70%. The aim of the study was to compare the nodule prevalence in two population-based studies, carried in Bulgaria in 2006 and 2012.Material and methods: Two thousand four hundred and two subjects (1347 female and 1053 male, age range 20–94 years) were included in 2006 and 2022 (1073 female and 949 male, 20–88 years) in 2012. All subje...

Background: National paediatric diabetes audit (NPDA) provides comparative data for local paediatric diabetes units (PDUs) on key care processes and overall HbA1c. More detailed analysis on other variables affecting HbA1c is undertaken at a national level, but not at an individual PDU level.Objective: To determine the factors influencing glycaemic control (HbA1c levels) in young children and adolescents with Type 1 Diabetes Mellitus (T1DM).<p class="...

Background: Diabetic ketoacidosis (DKA) is a common presentation of newly diagnosed type 1 diabetes (T1DM) in children but increases the disease burden at diagnosis. In UK, average frequency of DKA presentation is reported as 25% with an international variation of 16 to 67%. Data on frequency variations within the UK is limited.Aim: To compare the demographic and clinical characteristics of DKA vs non-DKA presentations in children <16 years at diagno...

Background: Post-thyroidectomy hypocalcaemia is a common complication with significant short and long term complications. The aim of this study was to determine the incidence and predictors of post-thyroidectomy hypocalcaemia (corrected calcium <2.1mmol/l).Method: A total of 183patients who underwent total thyroidectomybetween 2012 and 2015 in a national general hospital were included in this retrospective study. Clinical and biochemical data were ob...