Endocrine Abstracts

According to previous research microRNA (miR) are expressed differently in corticotropinoma and ACTH-secreting neuroendocrine tumors. MiR are released into circulation by several mechanisms and considered to be promising biomarkers.Objective: To evaluate whether preselected miR are differently expressed in plasma samples of patients with ACTH-dependent Cushing’s syndrome (CS).Materials and methods: The blood samples were colle...

Introduction: A growth hormone-secreting pituitary adenoma (GH-PA) increases the risk of complications and death. It’s management is determined by MRI data and decrease of insulin-like growth factor-1 (IGF-1) during the octreotide suppression test (OST). Currently, there is evidence that MRI-T2-hypointensive somatotropinoma and high expression of somatostatin receptors type 2 (SSTR2) according to immunohistochemical analysis (IHC) predict high efficacy of somatostatin ana...

Introduction: Recent studies have shown that microRNA could serve as biomarkers in various types of cancer and other diseases. Aim: To reveal microRNA that differ in patients with Cushing’s diseases (CD) and Ectopic ACTH-syndrome (EAS) to form a specific panel for differential diagnosis of ACTH-dependent Cushing’s syndrome (CS).Materials and Methods: Plasma samples from both sinuses and cubital vein were drained during in...

Purpose: Inferior petrosal sinus sampling (IPSS) is considered the gold standard test for the differential diagnosis of ACTH-dependent Cushing’s syndrome, but false-negative results have been reported in 1–10% cases. Cavernous sinus sampling (CSS) was suggested as a diagnostic tool in a complex ACTH-dependent Cushing’s syndrome cases.Aim: To study the role of bilateral combined cavernous and inferior petrosal sinus samplin...

The nicotinamide adenine dinucleotide (NAD+) dependent Poly-(ADP-ribosyl)polymerase 1 (PARP1) generates the post-translational modification ADP-Ribosylation (ADPR). Molecular studies have identified potential for NAD+ consuming enzymes to influence metabolic function. Given that PARP1 determines cellular NAD+ concentrations and ADPR shifts target protein activity, we sought to identify the molecular actions of PARP1 within skeletal muscle. Analysis of C2C12 lysates demonstrate...

• A 54-year old Lithuanian man presented with symptomatic hyperglycaemia and weight loss.• A diagnosis of new onset diabetes type 2 was confirmed for which he received treatment. In addition, his serum potassium remained low despite of intervention.• CXR was done and showed a bulky right sided hilar mass.• The combination of refractory hypokalaemia, hyperglycaemia, and lung cancer suspicio...

Background: Hypertension (HT) is common in adults with Turner Syndrome (TS) but less is known about HT in children with TS.Aim: To determine the frequency of HT in girls with TS in West of Scotland and to assess its association with clinical characteristics. Patients and methods Retrospective cross-sectional analysis of 126 girls with TS in the West of Scotland, with at least 2 clinic blood pressure (BP) measurements in the preceding 12 months. HT was de...

Introduction: For the last 2 years we have been giving regular diabetes education sessions in conjunction with our hospital school, based around maths skills. These went well, but we wanted to develop these further, making them more patient centred. We gained a grant from the Diabetes Research and Wellness Foundation and designed a 4 day programme with ‘The Puppet Project’ and ‘WAC arts’. This was done very much in collabaration with our hospital school who...

Currently, it has been established that obesity is a heterogeneous disease. There are metabolically healthy (MHO) and metabolically unhealthy obesity (MNHO) depending on the presence of cardiometabolic disorders. Potential factors that differentiate obesity into phenotypes include the gut microbiome and endocrine activity of adipose and muscle tissue. Purpose of the study was to compare intestinal microbiome and adipomyokine profile in patients with different obesity phenotype...

Background: Detection of MRI-negative ACTH-producing pituitary adenomas is a challenge inthe management of patients with Cushing’s disease. There are some data on theability of pituitary adenomas to accumulate 18F-fluorodeoxyglucose during the 18F-FDG positron emission tomography and computer tomography (18F-FDG PET/CT). Aim: To study the potential of using a standardized uptake value (SUV) and a tumor &...