Endocrine Abstracts

The key factor in the pathogenesis of both T2D and NAFLD is insulin resistance, which causes the lipids accumulation in hepatocytes and an increase of the lipid peroxidation, the production of reactive oxygen species and the development of inflammation. It has been shown that the main metabolic products of the saccharolytic microflora-short-chain fatty acids (SCFA), such as acetic (Ac), propionic (Pr) and butyric (Bu), can have an anti-inflammatory effect through their suppres...

Objectives: Orbital radiotherapy (OR) is the most commonly used second-line treatment for the severe forms of Graves’ orbitopathy (GO). The aim of our study was to assess the changes in the therapeutic response, ocular manifestations of GO and quality of life (QoL) during the first year after OR.Methods: The study involved 26 consecutive patients with active moderate-to-severe GO indicated for OR, 18 females, mean age 57±12.5. At baseline all pat...

Hypogonadotropic hypogonadism is a syndrome which may be manifested clinically by low sex steroids because of low (or inappropriately normal) gonadotropins. To date, more than 30 genes were reported as possible reason for this condition, but genetic basis is still unknown for ~60% of HH cases. Due to this fact we decided to analyze mRNA expression of several HH-related genes which can be found in leukocytes of peripheral blood: GNRHR and GNRH1 (which are necessary for adequate...

Background: Plasma microRNAs (miRs) (miR-4446-3p, miR-215-5p, miR-342-5p) were downregulated in patients with active acromegaly (AM) compared with healthy control subjects as assessed by next-generation sequencing.Aim: The aim of this study wasto validate the previously observed finding in the newly enrolled patients with AM using qRT-PCR.Materials and methods: Morning plasma samples were collected from fasting patients with AM and...

Introduction: In August 2015, the British Society for Paediatric Endocrinology and Diabetes (BSPED) released new guidelines for the management of DKA. These new guidelines recommended a much more conservative approach with fluid management in order to reduce the risk of cerebral oedema.Aim: Based on local anecdotal evidence, we hypothesized that with the new guidelines, we have had to increase maintenance fluid infusion rates more often and that the chil...

The aim of this work was to study the condition of the reproductive system after long-term administration of letrozole followed by its withdrawal in young males and against the background of involutive changes in aging males in a comparative aspect. The experiments were carried out on Wistar rats with an initial age of 5 months and 15 months, which have been gavaged by letrozole every other day at a dose of 1 mg/kg body weight for 3 months and then 2 months after its discontin...

Background and aims: The safety of thyroid surgery in terms of recurrent laryngeal nerve palsy and hypoparathyroidism was increasing in the last decade. In this study, we present a new method of tension-free thyroidectomy (TFT), which could be used to further decrease the complication rate after thyroidectomy.Patients and Methods: TFT is based on the medial approach to the recurrent laryngeal nerve (RLN) and the parathyroid glands after the division of i...

We present the case of a 32 year old woman presenting to her GP with right lower leg pain. This pain was worse at night, but responded to simple analgesia. She was initially diagnosed with arthritis but the leg pain worsened and became bilateral. She had no other significant past medical history with no history of fevers, trauma, fractures or dental problems. She had no relevant family, social or medication history.On examination, ...

A 46-year-old lady was referred to endocrinology with thyrotoxicosis. She was diagnosed with Graves’ disease by her GP in October 2016 when presenting with classical symptoms and investigations [TSH<0.01 mIU/L (NR 0.3–4.2), fT4=34.3 pmol/L (NR 9–23), TSHrAb>30 u/mL (NR<0.4), and increased iodine uptake]. She was therefore started on carbimazole 15 mg/day. She returned to her GP in December 2016 reporting resolved symptoms, however, she ...

We present the case of a 32 year old woman presenting to her GP with right lower leg pain. This pain was worse at night, but responded to simple analgesia. She was initially diagnosed with arthritis but the leg pain worsened and became bilateral. She had no other significant past medical history with no history of fevers, trauma, fractures or dental problems. She had no relevant family, social or medication history.On examination, ...