Endocrine Abstracts

Disordered eating is more common amongst people with type 1 diabetes than their peers without this condition. Anorexia nervosa, bulimia, eating disorder not otherwise specified (EDNOS) and deliberate insulin omission are more common in type 1 diabetes. Binge eating disorder is more prevalent in type 2 diabetes. These disorders present difficulties and dilemmas in personal diabetes management on a daily basis, and significantly increase risk of diabetes complications, particula...

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are grouped according to the origin of the primary tumor and their proliferation index (Ki-67). The WHO classification divide GEP-NETs into G1 (Ki-67 <3%), G2 (Ki-67 ≥3-20%) and G3 (Ki-67 >20%). Both parameters are accounted for when treatment strategies are planned. Furthermore, the presence of hormone related symptoms warrant consideration.Aim: To describe the treatment l...

TSH receptor antibody (TRAb) assays are highly sensitive and specific for the diagnosis of Graves’ disease. TRAb can minimise need for additional radiological modalities such as ultrasound and isotope scan in excluding other causes of hyperthyroidism. The relapse rates of hyperthyroidism following a course of anti- thyroid drugs (ATDs) remains disappointingly high at between 50-70%. TRAb levels at diagnosis and at the completion of a course of ATDs can be useful in predic...

Aims: To discover the views of patients with Diabetes Insipidus (DI) on difficulties they encounter with managing DI in different circumstances; the possible causes of these difficulties and how these might be improved for their safety.Background: Between 2009 and 2015 there were 471 serious adverse inpatient incidents and 2 deaths involving DDAVP administration1. The analysis of one death resulted in a suggestion that the name of the conditio...

Not everyone who has the capacity to make positive choices about their lifestyle to care for their health is either ready or willing to make these choices. This lack of interest is frustrating for both family members and healthcare professionals. Many young people living with diabetes understand why caring for diabetes is important but do not see it as a priority and do not have the confidence to put different behaviours into practice. Confidence to change requires the young p...

Gonadotropin releasing-hormone (GnRH or LHRH) regulates the hypothalamo-pituitary-gonadal (HPG) axis in vertebrates. GnRH neurons that regulate the HPG axis derive from progenitor cells in the nasal compartment and migrate along vomeronasal fibers across the cribriform plate into the forebrain. GnRH neurons migrate over a long route that provides many factors for guidance. Early in their migration, GnRH neurons always follow fibers; if fiber trajectories are altered, GnRH neur...

Introduction: Thyroidectomy can performed by open or wide array of endoscopic techniques. Lack of uniform consensus on specific indications for each technique leads to confusion on ideal thyroidectomy technique. In this context, we analysed our experience with specific emphasis on deducing an algorithm on ideal technique for a given patient. Material and methods: This is a retrospective study conducted at a tertiary care endocrine surgery department in S...

Shared, informed decision making is a key component to high quality care in the NHS. This can occasionally be challenging through lack of time, lack of high-quality trial evidence to support treatment choices and financial limitations to treatment. Informed decision making includes open discussion of the risks and potential adverser consequences of treatment and alternatives. People with endocrine disorders often have symptoms that encompass both their psychological and physic...

The obesity epidemic has affected many nations. In Canada, by some estimates, more than 6 million Canadian adults age 20 to 64 are overweight and nearly 3 million are obese. The common tendency is to blame people’s dietary choices and sedentary habits. Yet, it can also be argued that poor urban planning practices have largely contributed to a lack of active lifestyles. Low-density suburban sprawl, long commutes, diminishing land for green area and the elimination of sidew...

Treatment of osteoporosis is all about prevention of fractures. It relies on a combination of approaches, including adjustments to the patient’s diet and lifestyle, pharmacological therapy, and patient education. Changes to the patient’s diet and lifestyle typically involve: optimizing calcium and vitamin D intake and exercise levels, cessation of smoking and reducing alcohol consumption. Pharmacological therapies used to treat osteoporosis by reducing the fracture r...