Endocrine Abstracts

Prevention of disease or severe complications is the intended hallmark of modern medicine. Currently available diagnostic methods allow the early recognition of an increasing number of diseases allowing timely treatment and hopefully better long-term outcomes. The best examples of this strategy are genetic diseases and every week the genetic cause for another disease is identified. Therefore, the understanding of the practicing clinician the nature and pitfalls of genetic test...

Human health is influenced by diet composition as well as total energy consumption; however, the circuits that control hunger and food-seeking in general are better understood than the interoceptive mechanisms that lead to consumption of specific nutrients, though the latter may impact both total energy intake and the health quality of food choices. Thus, a better understanding of the biological basis of palatable nutrient appetite is needed to improve diet quality and human h...

Haematopoietic stem cell transplantation (HSCT), also known as bone marrow transplantation, is a potentially curative therapy mainly indicated in malignant and non-malignant bone marrow disorders. It has resulted in improved survival for patients at the cost of long-term complications. Endocrine and metabolic disorders are the most prevalent sequelae following bone marrow transplantation, primarily caused by powerful conditioning chemotherapy associated with total body irradia...

Introduction: Hypoglycaemia is one of the most important acute complications of diabetes. The fear of hypoglycaemia has a significant effect on the quality of life of patients and their families. It also remains a major barrier to achieve optimal glycaemic control. The GluCare Health care model is centered on the use of Continuous Metabolic Monitoring (CMM) and behavioural change to address metabolic diseases in a continuous manner. The Glucare program aims to provide continuo...

Objective: The purpose of this study was to evaluate the psychometric properties of a novel, patient-reported outcome (PRO) measure, the Hypoparathyroidism (HPT) Symptom Diary (HPT-SD), using data collected during a cross-sectional, noninterventional, observational study. The HPT-SD, developed according to the US Food and Drug Administration PRO guidance, addresses the severity of key symptoms (muscle cramping, tingling and muscle spasms/twitching, fatigue, cognition, emotions...

Context: Weight reduction in obese patients with type 2 diabetes mellitus (T2DM) leads to hyperglycaemia improvement and reduces complications. Thus it is important to investigate the potential benefits of the use of different dietetic approaches on weight loss.Objective: To examine the efficacy of two different dieting methods on weight loss in patients with T2DM.Materials and methods: 30 participants with T2DM, 18 men and 12 wome...

Background: There are a variety of growth hormone delivery devices (GHDD) available to children requiring growth hormone (GH) therapy. Many paediatric endocrine nurses can offer patients and their families a choice of the products that are available, which can sometimes be overwhelming. However, factors such a licenced clinical indications have to be considered, as well as cost. This study explored nurses viewpoints on GHDD.Aim: The purpose of this proje...

Corticosteroid hormones are synthetized in the adrenal glands and reach many organs including the brain. Within the brain they exert their actions through mineralocorticoid (MR) and glucocorticoid receptors (GR). These receptors generally act as transcriptional regulators and change the function of brain cells in a slow manner, with effects appearing after approximately one hour. However, in the past decade it has become evident that corticosteroid receptors also change brain ...

The financial markets represent the largest and most intense competitive forum ever constructed. Here, according to classical economic theory, competition drives optimal allocation of capital to projects with the highest returns, thereby promoting global prosperity. However, financial markets can be volatile, cycling between ‘bull’ and ‘bear’ states, and threatening the stability of the global economy.Bull markets can morph into bubbl...

Corticosteroid hormones are synthetized in the adrenal glands and reach many organs including the brain. Within the brain they exert their actions through mineralocorticoid (MR) and glucocorticoid receptors (GR). These receptors generally act as transcriptional regulators and change the function of brain cells in a slow manner, with effects appearing after approximately one hour. However, in the past decade it has become evident that corticosteroid receptors also change brain ...