Endocrine Abstracts

The treatment of craniopharyngiomas remains controversial, as no prospective randomized study has been performed. Although it is a benign tumour it may be life threatening because of its malignant growth and high recurrence rate. Compared to the general population, patients with this tumour has a 5-9-fold excess of mortality. The recurrence rate of the tumour seems to be dependent on the extent of tumour removal, the patient's age, and time of follow up. Primary radical surger...

There are a range of screening and diagnostic tests for the investigation of short stature, some of which are unpleasant and even dangerous for the patient. Growth hormone (GH) heterogeneity and wide assay biases cause additional complications for interpretation of results. We have used questionnaires to assess protocols and practice in the investigation of short stature by paediatricians and clinical biochemists in Wales.Responses from laboratory staff ...

In women, the anti-Mullerian hormone (AMH) is secreted by the granulosa cells of the growing follicles. Its assay is therefore strongly correlated with the antral follicular count and represents a reliable marker of the ovarian reserve. It also has the advantage of being very reproducible since it has little intra- and inter-cyclic variation. However, it seems to be a good quantitative reflection of the ovarian reserve but not qualitative. This drawback does not make this assa...

Introduction: Parathyroid adenoma is the most common cause of primary hyperparathyroidism. Effective preoperative imaging and localizing the parathyroid adenoma is a prerequisite for the surgical treatment. 99mTc-MIBI scintigraphy in combination with ultrasound of the neck are the imaging modalities of choice before parathyroidectomy. However, both have limitations in terms of their efficacy in localizing the adenomas; 11C-Methionine or 18F-Fluorocholine PET/CT has ...

Introduction: In type 2 diabetes the choice of the second drug after metformina is marked by the basic characteristics of the patient.Objetive: To analyze in real clinical practice the effectiveness of different antidiabetics.Material and methods: Observational study including patients with type 2 diabetes, in which we added to metformina different antidiabetics. We revised them 3-6 months from change.Results...

Background: Hyperprolactinemia is a common endocrine disorder. Yet, data on clinical profile of Nepalese patients with hyperprolactinemia is missing. The aim of this study was to assess the clinical profile of Nepalese patients with hyperprolactinemia.Methodology: Retrospective clinic based study conducted at the endocrine centre Kathmandu Diabetes and Thyroid Center, Lalitpur, Nepal, in which data was collected from the patient record files of the subje...

IntroductionProlactinomas are the most common pituitary tumors and a common cause of infertility because of gonadal dysfunction, in young women. The treatment of choice is dopamine agonists, which can restore fertility and promote shrinking of the tumor in the majority of cases. Managing prolactinomas during pregnancy may be challenging. Treatment discontinuation is recommended once the pregnancy is confirmed in women with microprolactinoma. For micropro...

BackgroundParaganglioma of the urinary bladder is rarely encountered. Its clinical signs and symptoms are usually nonspecific.Case presentationWe report a case of a 48-year-old woman who presented with recurrent hematuria for last 2 months with a recently detected hypertension. Computed tomography (CT) revealed a lobulated mass arising from the posterior wall of the urinary bladder and protruding into the ves...

IntroductionGerm cell tumour are embryonic tumour localized mainly at the gonads level, their cerebral localization is rare with less than 1% of intracranial neoplasia.ObservationWe have reported a 20 years old girl case without pathological history who had progressive diabetes insipidus for one year associated with spaniomenorrhea, the MRI revealed an aspect suggesting a pineal stem germinoma (12 mm of major...

IntroductionSomatotropic adenomas in the elderly are rare, and characterized by diagnostic delay and non-specific clinical signs. We report three cases of acromegaly discovered at a late age.ObservationThey are three women aged 66, 68 and 77 respectively. The circumstance of discovery of acromegaly was goiter in the first case (P1), poorly controlled diabetes in the second case (P2) and dysmorphic syndrome in...