Endocrine Abstracts

Thyroid cancer in children at the age of 0–14 year is a rare case and according to 2018 y. sta-tistics, it comprise 4% of total endocrine system cancer. This article describes clinical case of 14 years old boy with the solid form of thyroid carcinoma and the diagnosis was based on the surgical tissue examination. According to planned ultrasound investigation 2 cm nodule was revealed in the left lobe of thyroid gland without involvement in lymph nodules. Blood test of TSH...

Calcitonin assays remain a key requirement for the diagnosis and monitoring of medullary thyroid carcinoma (MTC). Until recently calcitonin assays were mainly competitive radioimmunoassays (RIA) but there are now more specific immunometric assays (IMA) available. Cost and staffing pressures are emcouraging routine clinical chemistry laboratories to perform easier kit methodologies rather than refer samples to specialist centres. However, endocrine tumours are known to secrete ...

We report new estimates of the disutility associated with GL and PL, and the quality of life (QoL) impact of leptin replacement therapy (LRT) based on two methods. The first approach estimates utility decrements associated with a range of impairments related to lipodystrophy through a discrete choice experiment (DCE) conducted with members of the general public; the second elicits QoL estimates from 8 PL patients using the SF-36 instrument. To characterize QoL consequences of ...

Objectives: Acromegaly may arise with several clinical presentations and cardiac involvement is the most important factor affecting the course of the disease.Case: A 32-years old man admitted to hospital complaining with shortness of breath. After initial evaluation he was diagnosed as ‘cardiac failure’. Cardiac evaluation revealed that he had ‘dilated cardiomyopathy’ with ejection fraction (EF) of 20%, global hypokinesia without valv...

Background: Maternal thyrotoxicosis affects 0.2% of pregnancies. Pharmacological treatments include carbimazole, methimazole and propylthiouracil. The Endocrine Society recommends the use of propylthiouracil as first line during pregnancy, because of possible associations between carbimazole and congenital anomalies. However, recent reports link propylthiouracil to liver injury in adults, children, pregnant women and fetuses, raising questions over its safety.<p class="abs...

The importance of controlling energy balance in weight management is well established. Theoretically only a small daily adjustment in energy intake should, in time, yield significant weight loss. However, this small behavioural adjustment seems very difficult to sustain for most individuals trying to loose weight. Interventions are often developed on the assumption that appetite expression and eating behaviour in the overweight and obese functions similarly, all be it less eff...

Different diets have been used clinically and/or have been rigorously assessed in the context of clinical trials in the past several years. Relative efficacy in terms of weight loss and improvement of cardiovascular outcomes will be presented. In addition, recent data have emerged on the role of leptin in mediating the neuroendocrine response to long-term caloric derivation and will also be presented along with novel data on leptin resistance. Leptin, alone or in combination w...

Objective: The aim of our study was to investigate the characteristics of the acromegalic patients followed at a tertiary Universitary Hospital and to evaluate the results of the recommended treatment protocols.Patients and methods: All our acromegalic patients were included (n=48; 27 women). Demographic, hormonal, visual and imaging data at diagnosis and during follow-up, as well as treatments applied, were recorded.Results...

Three eagerly awaited large, randomised, controlled cardiovascular safety trials with new antidiabetic drugs have recently been completed. The results of these studies are of wide interest to the diabetes and cardiology clinical scientific communities, and the results have been presented at diabetes and cardiology scientific meetings. These have studied drugs in each of the new classes of antidiabetic drugs: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor; lixisenatide...

Background: Nonivasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and hyalinizing trabecular tumor (HTT) are a rare follicular- derived thyroid neoplasmas with indolent clinical behavior. These tumors are encapsulated or clearly delimited and distinguished by detail using histopathological criteria.Method: Description of two cases of these rarer tumors, classified on FNAB Bethesda III AUS/FLUS in the BSRTC 2017 and diagnosed...