Endocrine Abstracts

The aim of our study was to evaluate the short term efficacy of radioiodine therapy (RIT) to reduce thyroid volume with minimal risk of hypothyroidism in patients with non-toxic nodular goitre. Material and Methods: We treated 120 patients, aged 20–76 years; (88%) of the studied groups were female and (12%) male. Initial 24 h RAIU was ranged between 22–44% and effective half-life was more than 3 days. Thyroid volume ranged between 42–170 ml. Malignant changes we...

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies, affecting 5–10% of premenopausal women. Anovulatory infertility is an important feature of PCOS and the optimal treatment for infertile women with PCOS has not yet been defined. Weight loss is recommended as the first-line therapy in obese women with PCOS desiring pregnancy. It is clear that regular physical activity is an important component of weight loss programs since it is associated with be...

Synthetic levothyroxine (L-Thyroxine) is the treatment of choice for hypothyroidism. It is safe, effective and generally well tolerated. Some patients, however, cannot tolerate L-Thyroxine. There is still some controversy about the effectiveness of combination T4 & T3 therapy. We describe 3 patients who were successfully treated with Armour thyroid (pork extract of T4 & T3) after being intolerant to L-Thyroxine.A 35 yr old lady initially presente...

Aim: Thyroid cancer (TC) is the most common endocrine malignancy, presenting a rising incidence during the last decade, due to continuously rising prevalence of incidental thyroid microcarcinomas (mITCs; ≤1 cm) in benign thyroid diseases treated with total thyroidectomy (TT). Solitary thyroid nodule (STN) is a thyroid condition, which remains under debate regarding the extent of thyroidectomy needed (total or near-total thyroidectomy vs unilateral lobectomy). Objective o...

IntroductionParaneoplastic hypercalcemia is extremely rare in the pediatric population, requiring urgent treatment. Pediatric malignancy-related hypercalcemia (PMRH) has been associated with rhabdomyosarcoma (RMS). Hypercalcemia with elevated parathyroid hormone (PTH), ectopic PTH secretion, is rarer (< 1% of cases). Reports of the use of Zoledronic Acid (ZA) as a second line bisphosphonate are limited. The monoclonal antibody, Denosumab, which inhib...

After total thyroidectomy, patients with differentiated thyroid cancer are treated with 131I activities aimed at ablating any remnant thyroid tissue and potential microscopic residual tumor. This procedure decreases the risk of locoregional recurrence and facilitates the long-term follow-up. In addition the high activity of 131I allows obtaining a highly sensitive post-therapeutic WBS. Radioiodine ablation is recommended in high-risk patients and in low-r...

Introduction: Small-group teaching (SGT) has been widely adopted in medical education to promote problem-based learning and enhance the process of deep learning. Simulation via Instant Messaging - Birmingham Advance (SIMBA) is a simulation-based learning approach using WhatsApp and Zoom to increase participants’ confidence in managing various clinical scenarios.Aim: To investigate whether SIMBA provided similar knowledge and experiences as compared ...

Introduction: Adrenal venous sampling (AVS) is the criterion standard method of lateralisation in primary aldosteronism (PA). Despite this pivotal role, there is limited consensus and significant variability between centres related to many of the technical aspects of AVS. In this study, we sought to address whether variations in two different technical aspects of AVS altered parameters and interpretation, namely: 1. Peripheral sample site 2. Method of adrenal vein (AV) venesec...

Primary hyperparathyroidism (PHP) is the most common aetiology for hypercalcaemia. Its prevalence in pregnancy is reported to be between 0.15% and 1.4%[i][ii]. It presents a threat to the health of both mother (hyperemesis, nephrolithiasis) and foetus (foetal death, congenital malformations, neonatal severe hypocalcaemia induced tetany)[iii][iv]. However, there is a lack of clear guidance on management of primary hyperparathyroidism in pregnancy. We describe the ...

Introduction: The global impact of COVID-19 has been unprecedented. Specific recommendations for the management of neuroendocrine disorders in the pandemic were rapidly released by Endocrine experts. To comply with COVID rules, NET patients, due to attend the endocrine unit in March 2020 for Somatostatin analogue therapy, were rapidly identified. 25 vulnerable patients had urgent domiciliary administration arranged. Other patients were taught to self-inject. Postal surveys wer...