Endocrine Abstracts

Introduction: The treatment of prolactin adenomas is medical based on the use of dopaminergic agonists but the presence of an underlying valvulopathy makes the treatment by cabergoline delicate.Clinical case: We report the case of a 60 year old female patient, operated on for aortic valve disease, with moderate mitral leakage. On the occasion of a decrease in visual acuity; a prolactin macro adenoma is diagnosed In agreement with the cardiologist; we opt...

The ophthalmic management of thyroid eye disease has changed markedly over the last 2 decades: There has been a significant trend towards more surgical involvement in both the active disease phase (with orbital decompression for relief of optic neuropathy, or eyelid surgery for severe exposure keratitis) and in the quiescent phase – with rehabilitative decompression (rather than eyelid surgery) having become the procedure of choice for most patients with established propt...

Adjuvant treatment for post-menopausal women with early breast cancer (BC) includes aromatase inhibitors (AI), known to decrease bone mineral density (BMD). In this study, we investigate whether denosumab is a valid second option for patients unable to receive standard adjuvant i.v. zoledronic acid (ZA). In total, 212 patients have been evaluated after they did not receive ZA. Of those 194 were included. After evaluation by an endocrinologist, all patients were offered ZA as t...

NICE guidelines (2010) recommend two different GH provocation tests demonstrating subnormal peak GH levels to diagnose isolated GH deficiency (GHD). Choice of stimulation test varies in different units. In our centre, glucagon (GST) and clonidine (CST) stimulation tests are used to make a diagnosis of IGHD. IGF1 is done as part of the initial screening tests.Purpose of this study was to compare the GST vs CST and to establish if IGF1 level provided any e...

In microsmatic animals, the olfactory cues initiate wide variety of neuroendocrine and behavioural responses. These behaviours are under the influence of sex hormones however some neuropeptide plays pivotal role. Oxytocin is involved in various social behaviours in mammalian species. However, oxytocin-deficient (OTKO) mice successfully accomplish reproduction although females cannot rear their pups because of lack of lactation. Though oxytocin is not essential for sexual behav...

It is known that brown rice (BR) prevents obesity and type 2 diabetes in humans. Previous studies have shown that exaggerated endoplasmic reticulum (ER) stress in the hypothalamus of obese mice is linked to hyperphagia. Here we tested the hypothesis that BR might decrease ER stress in hypothalamus, leading to the attenuation the preference for dietary fat.Eight-week-old mice were randomly divided into three groups: the control, BR-containing diet, and th...

Introduction: Testosterone measurement by liquid chromatography tandem mass spectrometry (LC-MS/MS) is well accepted as the preferred technique for the analysis of serum testosterone in both males and particularly females. However variation is seen between LC-MS/MS assays and is most likely to be due to method differences between laboratories. One area of inconsistency amongst routine LC-MS/MS assays is the choice of internal standard. We investigated the effects of three inte...

Aim: Audit was undertaken to study patient profile, prevalence, treatment choice and interrelation between biochemical markers in vitamin D deficient children.Methods: Retrospective review of case notes for patients who had vitamin D measured over the period 5/2005 and 5/2010.Results: Study included 150 randomly selected patients from a total of 336. 99 (66%) were found to be deficient in vitamin D, 52 females and 47 males. Peak ag...

Modern methods of induction of ovulation and assisted conception techniques have offered renewed hope for many infertile couples, including those with genetic causes of infertility. Turner's syndrome is, of course, characterised by primary ovarian failure and although spontaneous ovulation and conceptions have occasionally been reported, (usually in mosaic forms of Turner's) these events are rare and unpredictable. Attempts to induce ovulation are futile. The most realistic ch...

Introduction: Timing of DSD surgery is debated. This study aimed to investigate outcomes of genitoplasty in CAH and assess patient’s opinion on surgery.Materials and methods: In this ethically approved prospective study, surgically treated CAH girls ≥16 years completed an electronic questionnaire.Results27 patients were contacted 13 completed questionnaires, 10 declined, 4 did not reply. Current median age 27 ...