Endocrine Abstracts

Introduction: Immunotherapy is an effective therapeutic choice increasingly prescribed in oncology. Endocrine toxicity is described among its side effects.Methods: A case of a patient treated with immunotherapy since January 2022 is hospitalized in the endocrinology department in Bichat Hospital.Results: Mr K, aged 46, treated with of anti-CTA4 and anti-PD1 inhibitors for melanoma. A month after the treatment the findings showed an...

Therapeutic response for medical therapy in hormonally functioning pituitary tumours is different in various types of tumours. While majority of prolactinomas respond well for medical therapy using dopamine agonists, in other tumours like somatotropinoma or corticotropinoma their response is significantly lower. In some case therapy resistance can occur. There are various factors determining the efficacy of medical therapy in patients harboring functioning pituitary adenomas. ...

To date, magnetic resonance tomography is generally considered the imaging method of choice for its premium resolution of lesions and surrounding anatomic structures. This is mainly due to the improved soft tissue contrast this method offers. Other advantages are the possibility of direct multiplanar imaging in sagittal, coronal, and axial orientations and the avoidance of ionizing radiation. The goal of all imaging studies in this region is to indicate precisely the location,...

There are a number of established and recently identified inherited or congenital forms of growth hormone (GH) secreting pituitary tumors. These may be caused by an abnormality in the genetic sequence of responsible genes including MEN1, AIP, CDKN1B, and PRKAR1A. Copy number variation for these and other genes may also contribute to pituitary tumorigenesis, such as duplication of the gene GPR101 in X-linked acrogigantism (X-LAG) syn...

Subclinical hypothyroidism (SCH), defined as a state of elevated TSH concentrations in the presence of normal free thyroxine and triiodothyronine concentrations, can be mild or severe according to the extent of TSH increase. The disease may be progressive or regressive, while the main cause of SCH is chronic autoimmune thyroiditis. However, treatment of SCH remains controversial, levothyroxine being the treatment of choice. It should be initiated in pregnant women and in patie...

Introduction: Pituitary apoplexy is a rare endocrine emergency characterized by the sudden onset of severe headaches, vomiting, visual abnormalities and pituitary dysfunction secondary to an acute hemorrhage or infarction within a pituitary adenoma.Subjects and methods: We report a retrospective study from 2000 to 2014 of 23 cases with pituitary apoplexy. Their mean age was 38.7 years ±10 years, with a male to female ratio of 2:1. All patients benef...

Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, menstrual disturbances and hirsutism. PCOS is also associated with a metabolic disturbance characterised by hyperinsulinaemia and insulin resistance. Women with PCOS are at increased long-term risk of developing type 2 diabetes (T2DM) and carry a significant risk factor profile for cardiovascular disease. Obesity amplifies both reproductive and metabolic dysfunction. A growing body of evidence ...

Multiple endocrine neoplasia (MEN) syndromes are rare autosomal-dominant disorders that predispose affected individuals to benign and malignant tumours involving two or more endocrine glands. Four major forms of MEN are recognised, each associated with the occurrence of specific tumours. MEN1 is due to germline-inactivating mutations of the MEN1 tumour-suppressor gene, and is associated with the occurrence of parathyroid, pancreatic islet and anterior pituitary tumours. MEN2 (...

Introduction: Retrospective study of patients undergoing thyroid surgery at the Hospital Virgen de la Luz, Cuenca (Spain) during the years 2010–2013.Material and methods: We evaluated data of 92 patients basically with nodular thyroid disease, who were studied and treated in our hospital.Results: Our series is made up of 92 patients (25% men and 75% women) with an average age of 52 years. The most common form of presentation (...

Adrenal hemangioma is a rare adrenal tumour usually presented as incidental finding in asymptomatic patients. Due to its radiographic features sometimes it’s difficult to differentiate them from other malignant lesions. We present a 55-years-old men admitted to our department with adrenal incidentaloma size 5×4 cm confirmed by MSCT scan. Active phaeochromocythoma was excluded by normal urinary catecholamines. Endocrine evaluations revealed normal midnight cortisol, w...