Endocrine Abstracts

Introduction: Platinum-etoposide chemotherapy is a globally established chemotherapy combination for EP-G3-NEC. However, there are many different schedules for such chemotherapy, and the preferred one for EP-G3-NEC has not been established.Methods: An international survey was created, and completed by colleagues with an expertise in the field of neuroendocrine neoplasms. The aim was to explore which schedules of platinum-etoposide chemotherapy are used a...

Background: The choice of hydrocortisone (HC) formulation for children with adrenal insufficiency necessitates considerations for dose accuracy, palatability, and practicality in everyday life to optimise medicine adherence and health outcomes. Recently, several diverse new formulations have become available in the UK, but no information is available on real-life patient preferences for the different formulations.Objectives: Explore patient and parent ex...

Background: Since the FDA-approval of Lu177-DOTATATE and I131-MIBG radiopharmaceutical therapies in 2018, there is emerging real-world experience with their use. Only a few institutions in the US have both therapies available. Here, we describe our experience with these agents for patients with pheochromocytoma and paraganglioma (PPGL).Methods: This is a retrospective evaluation of all patients with progressive, metastatic, PPGL referred for radiopharmac...

Background: Since their FDA-approval in 2018, both Lu177-DOTATATE and I131-MIBG radiopharmaceutical therapies are available at our institution for the treatment of pheochromocytoma and paraganglioma (PPGL). Tumor uptake of the radiopharmaceutical on pre-therapy imaging is a requirement for treatment. Here, we describe our experience with pre-therapy imaging, and how it relates to the tumor genotype and the therapeutic choice.Methods: This is a retrospect...

Teenagers and young adult survivors of congenital and acquired brain injury caused by developmental defects (e.g. septooptic dysplasias), brain tumours and their treatment, or intracerebral and systemic disease (e.g. histiocytoses and meningitis), are often both learning disabled and requiring lifesaving (cortisol and desmopressin) and life-enhancing (sex steroid, thyroxine, and growth) hormone replacement due to panhypopituitarism.Managing the parental ...

Introduction: Sensitivity and specificity of thyroid cytology in our series of thyroidectomies were evaluated.Material and methods: A retrospective, multicentre study of 1567 thyroidectomies performed in the eight hospitals of Castilla La Mancha (Spain) during the years 2010–2013.Results: The cytological results were benign in 37.6% of cases, malignant or suspicious of malignancy in 17.3% (10 and 7.3% respectively). In 4.1% of...

Introduction: We introduce a case involving the appearance of superior vena cava syndrome secondary to intrathoracic goitre. We discuss the diagnosis, prognosis and treatment applied to this pathology.Case report: A 67-year-old woman who presents respiratory distress, cough, and weight loss. After physical examination and a chest radiography showing a mass that occupied the upper and middle right lung lobes, a neoplasm is suspected and at first, palliati...

Being overweight or obese is by many people considered a lifestyle choice. It is primarily us healthcare professionals who worry about the health impact of obesity, however are we always right? Whom should we consider at risk and when should we (try) to intervene? Is there something like healthy obesity? This talk is aimed to reflect and understand what happens with adipose tissue when we gain weight, how it copes with surplus energy and how it links with obesity and its compl...

The manifestation of adrenal disorders during pregnancy is a rare but regularly occurring event and can pose significant problems for the involved medical professionals. This lecture will give an overview of the major management issues surrounding disorders of the adrenal cortex during pregnancy. This includes the requirements for the adjustment of corticosteroid replacement therapy in adrenal insufficiency, due to the physiological changes in corticosteroid secretion during p...

Maintenance of spermatogenesis depends on adequate gonadotrophin and intratesticular testosterone concentrations. Hormonal contraception for men interrupts this physiological axis by various means of gonadotrophin suppression; this induces reversible azoospermia or severe oligozoospermia in virtually all men. Clinical trials have confirmed that high contraceptive efficacy, similar to female hormonal contraceptives, can be reliably attained with few side effects. However, the s...