Endocrine Abstracts

Background: Male-to-female transsexual persons use estrogens + antiandrogens to adapt their physical bodies to the female sex.Estrogens are powerful stimulators of synthesis and release of prolactin and serum prolactin levels are usually somewhat increased following estrogen treatment.Objective: To determine prolactin levels and to assess the risk of development of prolactinoma in male-to-female transgender subjects following cross-sex hormone therapy (C...

Introduction: The oxidative stress is supposed to be key factor in multiple diseases.The aim of the study was to examine the effects of excessive GH secretion on the blood antioxidant system: total antioxidant capacity (TAC) of plasma; superoxide dismutase (SOD) and catalase activities (CAT); ceruloplasmin (CP); non-protein thiol (NT), and level of thiobarbituric acid reactive substances (TBARS).Materials: Eleven patients with acti...

The paper shows the data on diabetes mellitus occurrence in the population of northern Kosovo and Metohija (local inhibitants and displaced person). The research comprises results of 42 495 examinations in Unit of Internal Diseases of Medical Centre in Kosovska Mitrovica in theperiod of January 2000–December 2002 (14 000 examinations on average, annualy). Diabetes was diagnosed and classified on the basis of the latest internationally recognazed criteria in 280 580, that ...

Diabetes mellitus type 2 (DM2) is affecting physical and psychological health.Objective: Compare anthropometric data, body composition, lipids levels, emotional state, quality of life (QoL) of DM2 patients and that of healthy persons of the same age.39 persons (58.1±9.6 years) with DM2 (18 male, 21 female) and 41 healthy persons (54.3±9.9 years) (22 male, 19 female). Profile of Mood State (POMS) used for emotional state e...

For quite a long period of time, diabetes mellitus (DM) has been considered as the carbohydrate metabolism disorder; to maintain blood glucose normal was believed to be the only mission of insulin. By now, findings from many studies have proved that DM is accompanied by the complex disorder of metabolism not only for carbohydrates, but also for lipids and proteins. Atherosclerotic injury of large vessels and ketoacidosis are known to be the main DM complications. The work was ...

Introduction: Current guidelines from The Endocrine Society indicate that 2 different tests from urinary free cortisol (UFC) measurement, salivary cortisol (SC) measurement, low-dose dexamethasone suppression test (LDDST) or overnight dexamethasone suppression test (ODST) are required to diagnose Cushing’s syndrome (CS). The low-dose dexamethasone test (LDDST) is often used as the confirmatory test when diagnosing CS. The overnight d...

Introduction: Current guidelines from The Endocrine Society indicate that 2 different tests from urinary free cortisol (UFC) measurement, salivary cortisol (SC) measurement, low-dose dexamethasone suppression test (LDDST) or overnight dexamethasone suppression test (ODST) are required to diagnose Cushing’s syndrome (CS). The low-dose dexamethasone test (LDDST) is often used as the confirmatory test when diagnosing CS. The overnight d...

Introduction: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is documented as a pre-malignant condition by the World Health Organisation. Patients with pulmonary nodules typically undergo 5′-18fluoro-deoxy-D-glucose (FDG) positron emission tomography combined with computed tomography (PETCT) for further diagnostic investigation. DIPENCH is widely accepted as an FDG negative pathology. The purpose of this analysis was to a...

Objective: To evaluate and compare the effects of metformin used as a single-agent therapy and in combination with gliclazide modified release (MR) on glycoregulation and lipid profile in patients with type 2 diabetes mellitus (T2DM).Methodology: A multi-center observational epidemiological study was carried out in patients with T2DM, divided in two groups according to the current type of treatment: first group was on monotherapy with metformin in daily ...

Proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating protein that promotes degradation of the low density lipoprotein (LDL) receptor, has been emerged as a novel therapeutic target for the dyslipidemia. It is well known that the pathogenesis of cardiovascular disease (CVD) involves lipid metabolism alteration, but the predictive value of circulating PCSK9 level concerning coronary disease severity is largely unknown. The main objective of this study is to deter...