Endocrine Abstracts

Obesity is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality. Increasing numbers of reports concerning not only obesity, but diabetes, hyperglycaemia and lipid dysregulation in patients treated with antipsychotics have raised concerns about a possible association between these metabolic effects and treatment with these medications. The objective of our study was to investigate the prevalence of obesity and other m...

Subclinical thyrotoxicosis, defined as a low serum thyrotrophin (TSH) and normal serum free T4 and T3 concentrations, has been found in up to 3.2% of adults in cross-sectional surveys of thyroid function, of whom 75% have serum TSH concentrations of 0.1 to 0.4 mU/L. If the diagnosis is limited to only those with a serum TSH lower than 0.1 mU/L, the prevalence decreases to 0.7%, with 20% being treated with thyroxine.Thyrotoxicosis is considered overt only...

The silent myocardial ischemia is a serious diagnostic problem especially in patients with long-standing diabetes of type 1 (DM). Resting as well as exercise myocardial perfusion scintigraphy tests allow to recognize the silent myocardial ischemia in these groups of patients and to start the relevant treatment. The aim of the study was to establish the prevalence of myocardial ischemia in patients with type 1 DM, without clinical symptoms of ischemic heart disease (IHD) and wi...

Aim: To ascertain the types of treatment, results and correlation between GH and the simultaneous IGF-1. Setting: Endocrine and Neurosurgical Unit. Methods: Endocrine and laboratory database of 17 acromegalic patients (11 male) with mean (SD) age 51(3) years and follow up 11 years. Results: Pituitary surgery 11 patients (3 twice), external radiotherapy 10 (one heavy particle therapy). GH levels have come down from a median value 32.5 mU per litre (Mean plus/minus SEM: 51.9 plu...

IntroductionObesity is an important medical and social problem of our time, because its prevalence is growing rapidly and affects about 30% of the adult population of the planet. Obesity is characterized by an increase in the expression of cytokines that cause endothelial damage. It is known that prohormone thyroxine (T4) is converted into 5 times more active triiodothyronine (T3) in peripheral organs (such as live...

IntroductionThyroid autoantibodies can detected in many disorders not only at the Hosimoto autoimmune thyroiditis. Their level and frequency may vary depending on many factors both thyroidal and nonthyroidal. Anti thyroid peroxidase autoantibodies (ATPO) is one of the well known among them. We analysed frequencies of higher level of ATPO among people with different types of thyroid diseases.Material and methods<p class="abstext...

Background: Hypothalamic obesity (HO) is defined as abnormal weight gain resulting in severe persistent obesity due to physical, tumor- and/or treatment related damage of the hypothalamus. The HO epidemiology is poorly understood. We developed a database algorithm supporting the standardized identification of tumor/treatment-related HO (TTR-HO) patients.Methods: The algorithm is used to estimate incidence rates of TTR-HO patients in the German healthcare...

Introduction: Problem of evaluation of the motor activity patients undergoing medical rehabilitation and sanatorium treatment remains relevant, including obesity. Aim.: To study the nature and degree of disorders of muscle strength, motor and coordination functions in patients undergoing medical rehabilitation and sanatorium treatment. Material And Methods: Single cross-sectional study included 160 patients aged 40 to 65 years with...

As a cytokine, TNF-α plays a role of key anti-inflammatory mediator involved in the onset and progression of insulin resistance and type 2 diabetes mellitus. TNF-α is known to inhibit insulin-stimulated of auto-phosphorylation of insulin receptors by tyrosine kinase; as the result, insulin sensitivity decreases in its turn resulting in insulin resistance and glucose transport damage. TNF-α is a trigger in the onset of obesity, diabetes mellitus and its complicat...

Background: G3NETs demonstrate variable clinical behavior (Ki-67>20-100%). Treatment extrapolated from grade 1/2 (G1/2) NETs and neuroendocrine carcinomas depending on clinicopathologic features. Therapy for treatment-emergent G3NETs remains especially ill-defined.Methods: Retrospective chart review of patients with de novo G3NETs or progressing from low-to-high grade (L-H) (G1/2 at diagnosis and G3 >=3 months later). Treatment patterns compared ...