Endocrine Abstracts

Background and aimThe epidemic of overweight and obesity presents a major challenge to chronic disease prevention and health across the life course around the world. The putative relationships between thyroid hormones, body weight, and adipose tissue homeostasis have been the focus of several studies in recent years, but the causal relationships between these parameters have not been well established. Aim of the study: to investigate the relations...

Introduction: The prevalence of overweight and obesity is risen dramatically especially among children and adolescents. Increased BMI is an independent risk factor for cardiovascular diseases, diabetes mellitus, and some types of cancers (including endometrial, breast, ovarian, prostate, liver, gallbladder, kidney, and colon). Changes in dietary and physical activity patterns are often the result of environmental and social impact. Studies carried out revealed that people glob...

Obesity of varying severities can be seen in the vast majority of patients with type 2 diabetes mellitus (DM2). Oxidative stress is considered as a key pathogenetic link in the formation of metabolic disorders in obesity. The work was initiated to assess intensity of oxidative stress in obese patients with DM2.Materials and methodsThe patients were divided into 3 groups. Patients with DM2 and BMI > 30 kg/m2 were incl...

Background and Aim: Diabetes mellitus (DM) represents a substantial burden on health care systems, being the 8th leading cause of death and disability in the world in 2019, associated with long-term microvascular (neuropathy, retinopathy, and nephropathy) and macrovascular (ischemic heart disease, stroke, peripheral vascular disease) complications. DM comorbidities lead to a substantial decrease in quality of life, as well as important socio-economic consequences. In 2022, the...

Introduction: Recently, vitamin D3 (cholecalciferol) deficiency has been considered as one of the factors for the development of type 2 diabetes mellitus (T2D) and metabolic syndrome (MS), which contributes to increased insulin resistance (IR) and reduced insulin secretion. The most pronounced vitamin D deficiency is observed in persons suffering from morbid obesity. The aim of this study was to assess IR, b-cell functional activity and metabolic profile parameters according t...

Non-functioning pituitary adenomas (NFPA) are the most common pituitary tumours. They usually come to medical attention because of a mass effect and/or hypopituitarism. Tumour shrinkage during therapy with either dopamine agonists (DA) or somatostatin analogues (SSA) has been previously reported in some cases; however, response of NFPA to medical treatment is still poor and unpredictable. Our aim was to explore the molecular mechanisms underlying this lack of efficacy through ...

Background: Patients with transfusion-dependent β -thalassemia (TDT) often experience several endocrine complications, including diabetes mellitus (DM). In TDT, the reliability of glycated haemoglobin (HbA1c) assessment is compromised due to elevated erythrocytes turnover and frequent transfusions. Glycated Albumin (GA), a product of non-enzymatic albumin glycation, has been investigated as a medium-term glycaemic marker (21 days) in the general diabetic population. Since...

Introduction: Melatonin plays a key role in the circadian timing system. The question remains whether changes in endogenous melatonin may be associated with food intake. Orexin and ghrelin are involved in the regulation of energetic homeostasis. Therefore, we decided to obtain more detailed data on the circadian changes of orexin, ghrelin and melatonin for identification of the changes in these hormones to food intake and day-time, together with glycemic and C-peptide levels.<...

The objective of this study was to determine the correlation between serum zinc level and neutrophil respiratory burst in patients with type 2 diabetes mellitus. 40 type 2 diabetic patients (20 with foot ulcers) and 20 healthy controls were recruited. The local ethical committee approved the study, and written, informed consent was obtained from every participant before enrolment in the study. 20 millilitres of heparinized venous blood were taken from each individual in the fa...

Introduction: Ageing is associated with a decrease in activity of the growth hormone / IGF-1 axis. However, there is little normative data for serum IGF-I levels in the very elderly and the relationship of IGF-1 levels to muscle function and physical performance in geriatric inpatients has not been fully explored. We studied elderly patients rehabilitating after proximal femoral fracture (PFF), hypothesising that patients with lower circulating IGF-1 levels would have poorer p...