Endocrine Abstracts

Introduction: DM 1 is proposed as a condition of accelerated muscle aging and mitochondrial dysfunction as a common link regulating muscle deterioration in aging and DM 1. Loss of muscle mass is associated with insulin resistance, metabolic syndrome and cardiovascular complications.Objectives: To analyze body composition and metabolic variables related to insulin resistance in overweight/obese patients with DM1.Material and MethodsObservational, cross-se...

Type 2 diabetes causes excess cardiovascular mortality and microvascular disease. Therefore, the results of the EMPA-REG OUTCOME trial were received with great excitement, since this was the first trial with cardiovascular end points to show a benefit for persons suffering from type 2 diabetes. The striking benefit of a 38% reduction in cardiovascular mortality during SGLT2 inhibitor treatment was surprising and exceeded what was expected based on the relatively modest reducti...

The proline rich and Gla domain genes PRRG1-4 encode for short transmembrane proteins. PRRG proteins contain a Gla domain with glutamic acid residues which are gamma-carboxylated in a vitamin-K-depend manner. In a previous study, we were able to show a decrease in PRRG1 gene expression during intima thickening in atherosclerosis. In this study, we investigated the association of single nucleotide polymorphisms (SNPs) in the vitamin-K-dependent protein PRRG1 with cardiovascular...

Introduction: Animals have long been considered the best friends of man, but as it turns out, the degree of empathy towards them is ontogenic variable. So far there have been studies showing the influence of mutations in the oxytocin gene on our level of empathy.Method: It was decided to check if hormonal factors have the influence on our relations with animals. For this purpose, patients treated in our department of endocrinology were examined. The stud...

The research goal was to study serum concentration of immunoregulatory cytokines (IL-1ß, IL-6ß, IL-8ß, IL-10ß) in 80 patients with manifest hypothyroidism at the age of 21–50. 48 patients suffering from chronic autoimmune hypothyroidism and 32 patients with postoperative hypothyroidism were examined. It was revealed that autoimmune hypothyroidism effects balance disturbance of cytokine-producing activity Th1 and Th2 types, this plays an important role ...

Background: Peripheral arterial disease is a disorder due to obstruction of blood supply to extremities. Diabetes mellitus and hypertension are predisposing factors.Objective: To determine if the presence of concurrent hypertension increases the risk of peripheral arterial disease (PAD) in Nigerians with type 2 diabetes.Methods: This was a cross-sectional study that included 160 persons living with diabetes mellitus (60 subjects ha...

Introduction: Contradictory associations between sleep disturbances and changes in cortisol levels or unfavourable metabolic conditions like obesity and diabetes mellitus have been observed.The aim of the present study was to examine salivary cortisol in persons with reduced sleep quality and to evaluate the relationship between sleep quality and metabolic parameters.Methods: The Pittsburgh Sleep Quality Index (PQ8I) was used in 15...

Aim: To assess the quality of life of patients with nonfunctional pituitary adenomas (NFPA) and growth hormone deficiency (GHD).Materials and methods: Eighteen GHD patients with non-functional pituitary adenomas (NFPA), (12 F/6 M), aged 35.5±14.4 yr (mean±SD; range 23–58), body mass index (BMI) 28.6±0.6, with a history of adult-onset hypothalamic-pituitary disease, were recruited for the study. The examination included hormonal assess...

Introduction: Evaluation of sexual function is an integral part of general assessment of people with diabetes mellitus but this is rarely done. These comprises hypoactive sexual desire, erectile dysfunction (ED) and ejaculatory disorders. Presence of any of this will negatively impact on the sexual life of female partners.Objectives: To determine the frequency and determinants of sexual dysfunction among male patients with type 2 diabetes mellitus (T2DM)...

Background: Hyperglycaemic emergencies (HEs) continues to be important causes of morbidity and mortality among persons with diabetes mellitus. Hyperglycaemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) are the two most common acute metabolic complications seen in persons with diabetes mellitus.Objective: To describe the clinical presentation and outcome of patients with hyperglycaemic emergencies.Materials and methods:...