Endocrine Abstracts

During the Chernobyl nuclear power plant accident (ChNPPA) a mixture of radioactive isotopes, mainly the iodine and cesium, were released, which through inhalation and food, and in some cases along with external exposure had affected the hormone-producing cells of endocrine system. Within days and months after the accident, the thyroid and parathyroids accumulated a significant amount of these isotopes with thyroid gland becoming a secondary emitter, which further increased th...

In FtMs testosterone (TE) therapy is used to pursue the dual objective of suppressing female secondary sex characteristics and inducing a male phenotype to the patient. Between October 2001 and December 2018, an heterogeneous group of 32 patients (Pts) with a mean age of 27.7 years presented to our Center for FtM Gender Dysphoria. We analyzed Body Mass Index (BMI), haemochrome and hormonal (LH, FSH, Prolactin) measurements comparing baseline levels to post-therapy. A total of ...

Introduction: Sex steroid hormones exert a wide range of effects on metabolism. New techniques such as metabolomic profiling allow for a deeper insight into metabolic regulation. In epidemiological samples it has been demonstrated that most of these metabolites show sex-specific differences. However, if these differences are attributable to the effects of sex hormones or genetics is little understood so far.Methods: We performed targeted metabolomics pro...

Acute and chronic alcohol intake and alcohol withdrawal induce dysfunction of neuroendocrine and other regulatory systems. The aims of this study were to assess a possible hypothalamo-pituitary-adrenal (HPA) axis dysfunction in population of alcoholics, using dexamethasone suppression test (DST). The study was approved by local Ethical Committee. The serum and urinary cortisol were compared between the groups of 89 male patients (64.5% depressive and 35.5% nondepressive alcoho...

Background: Transpersons can receive gender affirming hormone therapy (HT) to induce physical changes. Little is known about the effect of HT on breast cancer (BC) risk.Objectives: To study the prevalence and characteristics of BC in transpersons with HT and to compare this prevalence with the general Dutch male and female population.Methods: Adult transpersons who were seen after 1991 and started HT in the VUmc were included. This...

BackgroundOnly limited data are available regarding adverse effects of gender affirming hormonal treatment (HT) mainly due to the lack of population-based studies with adequate controls, thus making spontaneous reporting systems a valuable tool to detect potential side reactions.ObjectiveIn this nationwide retrospective study, we aimed to analyse adverse drug reactions (ADRs) in relation to gender affirming H...

Background: Predictions estimate that the majority of the global population will be living with overweight and obesity by 2035. Due to its widespread use and ability to disseminate information, social media has a potentially prominent role in obesity care and education. Regulatory bodies issue ethical guidance on social media use. However, it is unknown how healthcare professionals’ (HCP) online activity affects people living with obesity. By exploring th...

Introduction: Many studies have pointed to the importance of chronic inflammation and dyslipidemia in the development of atherosclerosis, but data related to the elderly population are still inconsistent. The aim of the work: To determine the importance of determination of markers of inflammation (C-reactive protein - CRP) and lipid status in elderly (≥65 years), functionally dependent persons.Methods: A prospective study that included 257 patients...

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Background: Adolescence is a challenging time for people with type 1 diabetes (T1DM), associated with worsening glycaemia and disengagement with care. Educational interventions often focus on imparting diabetes-specific skills rather than attending to some of the broader psychosocial challenges young people commonly experience. To address this, we codesigned a psychosocially modelled programme of diabetes education, named ‘Youth Empowerment Skills’ (YES), with young ...