Endocrine Abstracts

Introduction: Diabetic foot ulcer (DFU) is a chronic complication not desired in individuals with Diabetes Mellitus (DM). It reduces the productivity and economic power of affected persons. Identifying risk factors leading to development of DFU is of paramount importance in preventing its occurrence.Objective: To identify risk factors for DFU in diabetes outpatient clinic of Lagos University Teaching Hospital.Method: This was a cro...

Background: Diabetes mellitus (DM) is a leading cause of morbidity and mortality globally. Its prevalence is increasing worldwide due to the transition phase. The present prevalence of DM is projected to double in the year 2035.Materials and methods: This is an ongoing prospective observational study. Subjects were persons who had been diagnosed of DM using the World Health Organization (WHO) criteria, and had been on treatment for at least six months. S...

Aims: The aim of our study is to assess the efficacy of lifestyle modification and picolinate chromium intake in preventing diabetes mellitus type 2 (DM 2)Materials and methods: The study included 100 patients (69 m 258 f) 25–65 years with impaired glucose tolerance (IGT) and newly diagnosed DM 2. Patients were divided into 2 groups matched by age, weight, body mass index (BMI), waist-to-hip ratio (WHR). Research group included 54 patients who carr...

In MtFs therapy with oestrogens and antiandrogens, actually considered the best strategy, requires a careful baseline and follow-up hormonal evaluation. We conducted a retrospective analysis to define the most frequent hormonal treatment prescribed and the relationship between the dosage and patients’ hormonal changes. Among 85 pts referring to us between March 2003 and June 2018 with a mean age of 28.4 years we have selected 42 treated with Oestradiol Valerate (OV) and C...

Introduction: Gender dysphoria refers to the incongruence between the subject’s experienced sex on the one hand and the assigned sex on the other hand. Several studies assume a relationship between oestrogen substitution therapy and serum prolactin levels.Aim: The aim of this study is to get more insight into the effect and time-course of changes in serum prolactin levels during cross-sex hormone therapy.Methods: This prospect...

BackgroundThe burden of disease in thyroid dysfunction (TD) is modifiable. Social domain of quality-of-life is a vital aspect of the biopsychosocial approach to management. Treatment decisions are increasingly guided by quality-of-life issues, creating a need to monitor the quality-of-life within clinical practice. Thyroid-specific patients reported outcomes scale/tool (ThyPro) was developed and used predominantly in populations in developed countries. W...

The sex-specific sex steroid profile seems to be associated to the gender differences between males and females on metabolic and cardiovascular risk (CVR). Objetive: to examine the effects of cross-gender sex steroid exposure on metabolic and CVR parameters. We incorporated 152 women transgender (WT), age (Median) 31 yr old (16–62) and 76 male transgender (MT) age: 25 yr old (17–53), treated at least by 1 year. WT received transdermal 17ßEstradiol (E2) 50 μ...

Introduction: There is a general assumption that glycemic control in persons with diabetes(PWD) has deteriorated since the onset of COVID-19 pandemic. We conducted this to compare the glycemic status of a very large cohort of PWD prior to COVID-19 outbreak with that of a similar cohort post onset of the outbreak. Methods: This was a retrospective study wherein entire data of glycated hemoglobin (HbA1c)% available in the hospital database since 3rd Octobe...

Introduction: Excess visceral adipose tissue (VAT) is strongly related to multiple cardiovascular risk factors such as dyslipidemia. Hormonal therapy (HT) in trans persons affects total body fat and body fat distribution, but the effect on VAT and its relation to changes in lipids is unknown. The aim of our study was to investigate the effect of one year HT on changes in VAT and its relation with changes in total cholesterol, HDL, LDL, and triglycerides after one year of HT.</...

Contemporary research data indicate that pancreatic beta cells are sensitive to ionizing radiation. Our recent studies showed a significant (2–3-fold) increase in the type 2 diabetes mellitus (T2DM) incidence in adults exposed to ionizing radiation in a young age within 1986–1990 time period compared to the entire population of Ukraine. Currently there are no data on the time pattern of content of proinflammatory cytokines TNF-α and IL-6 in the clean-up workers ...