Endocrine Abstracts

People are all different, and this is no different when we consider people with diabetes, yet the current approaches to management of diabetes tend to treat everyone the same. The field of precision medicine aims to recognise these differences – whether at the level of their phenotype or at the molecular level. Faced with multiple, and increasing, treatment options for diabetes as well as increasing healthcare costs there is a clear need to target therapy to maximise bene...

Introduction: Quality of life in transsexual persons after transition is among the most important outcome factors.Methods: A specialist center cross-sectional study in 193 transsexual women and 128 transsexual men (mean age 42.5 years) after on average 7.4 years of cross-sex hormone therapy and 6.6 years since sex reassignment surgery (SRS), compared to an age-and gender matched control population (1 to 3 matching). Self-reported physical and mental heal...

Objective: Transgender persons often experience low socioeconomic status. Gender affirming treatment aims to improve gender dysphoria. We assessed employment rates in transgender persons compared to controls and demographic, health and treatment-related factors associated with unemployment in transgender persons.Methods: National register-based cohort study in Danish transgender persons with diagnosis code of gender identity disorder during year 2000-202...

Background: Gender-affirming hormone therapy in transgender persons induces secondary characteristics of the experienced gender. However, androgens and estrogens are also thought to be involved in insulin sensitivity and research suggests a dose-dependent risk for developing insulin resistance when administrated in supraphysiological doses.Aims: To assess the influence of gender-affirming hormone therapy on glucose metabolism in transg...

Objectives: Gender affirming hormonal and/or surgical care is associated with reduced fertility. Over the last years, the options for transgender persons to fulfill their child wish have increased. Previous research (mainly focused on transgender persons visiting health care professionals) on fertility in transgender persons assigned female at birth (AFAB) shows low fertility preservation utilization. Ideas and concerns of AFAB transgender persons regarding fertility preservat...

This study was conducted to evaluate the frequency of PCOS in a group of FTM transsexual persons and its relationship between clinical, hormonal and metabolic characteristics.Subjects and Methods: We studied 21 FTM cases, aged 17–37 years, BMI 24.6±5.2. No patient reported previous hormonal treatment or sex re-assignment surgery. PCOS was diagnosed according to the Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group, 2004. World Health...

Objective: To describe the effects and side effects of cross-sex hormone therapy in both transsexual men and women.Design: Single center cross-sectional study in one hundred transsexual persons post SRS and on average 10 years on cross-sex hormone therapy.Methods: Hormone levels were measured by immunoassays. Physical health was assessed by physical examination and questionnaires on general health and specific side effects, areal b...

Objective: The aim of the current study is to examine the effects of gender affirming hormone therapy in transgender persons on calcium and phosphate concentrations and their regulatory hormones.Design: A prospective cohort studyMethods: This study investigated changes in calcium and phosphate concentrations and their regulatory hormones in trans women and trans men during the first year of hormone therapy. Trans women received est...

Introduction: Anger is an emotional state of feelings varying from mild irritation to intense rage, whereas aggression implies externalizing angry emotions through destructive/ punitive behavior towards other persons/objects. Although research on the relationship between testosterone and aggression is inconclusive, the WPATH SOC 7 guidelines have warned for an increase in aggression in transgender men (TM) taking testosterone treatment.Aims:<p class=...

Background: Gender affirming hormonal treatment (GAHT) is for many a cornerstone of transgender care. National data regarding use of hormonal treatment by transgender persons are limited.Aim: To assess use of GAHT in transgender persons.Design: National register-based cohort study in Danish transgender persons followed from 2000 until 2018. The main outcome measure was redemption of GAHT. Persons with an ICD-10 diagnosis code of &#...