Endocrine Abstracts

Objectives: Transgender persons undergoing gender affirming hormonal and/or surgical care, are at risk of reduced fertility. Although theoretically, the options for assigned male at birth (AMAB) transgender people to fulfill their child wish are extensive, research in transgender women shows low fertility preservation utilization. Ideas and concerns of AMAB transgender persons regarding fertility preservation and child wish have never been reported in a large, non-clinical sam...

Background: Vitamin D deficiency is very common in older persons. It is not clear how serum 25-hydroxyvitamin D (25(OH)D) levels change during aging.Objective: To examine longitudinal changes in serum 25(OH)D levels in two representative cohorts of Dutch older persons during 6 and 13 years of follow-up, respectively.Methods: Data of the Longitudinal Aging Study Amsterdam (LASA) were used, an ongoing cohort study in older persons. T...

Glucose-dependent insulinotropic peptide (GIP) contributes to incretin effect of insulin secretion which is impaired in type 2 diabetes mellitus. The aim of this study was to develop a simple meal test for evaluation of GIP secretion and action and to examine GIP changes in type 2 diabetic patients. Seventeen type 2 diabetic patients, 10 obese non-diabetic and 17 non-obese control persons have been examined before and after 30, 60 and 90 min stimulation by meal test. In a mixe...

Background: Several resting state networks have been described in literature. Today, it is still unclear whether these networks are stable or can be influenced by sex hormones. Transgender persons offer a unique opportunity to study these hormonal influences.Objective: To examine the effects of cross-sex hormone treatment in transgender persons on two resting state networks involved in cognition and emotion, the default mode network and executive network...

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are involved in the regulation of glucose metabolism and metabolic disorders. IGFBP1 is the only IGF-binding protein that shows diurnal variation and is inversely correlated to the insulin level. IGFBP1 exists as non-phosphorylated protein and several phosphoforms. Phosphorylation affects the affinity of IGFBP1 for IGFs and, therefore, the ability to regulate IGF action. In the circulation IGFBP1 is associa...

Background: Sex steroids probably stimulate growth-hormone secretion during puberty, which in turn contributes to the development of gender specific body characteristics. Hypothetically, adequate growth hormone levels in transgender persons are also important to achieve the best therapeutic results. The influence of cross-sex hormone treatment (CHT) at growth-hormone production in adult transgender persons is not yet elucidated.Objective: To investigate ...

BackgroundApart from long-term complications associated with diabetes(T2DM), the psychological impact also significantly contributes to poor outcomes in persons living with diabetes. An observational survey was undertaken to assess various physician-related factors that can help define “glycemic happiness” for persons living with T2DM.MethodsA prospective, multicentric, cross sectional, observationa...

Introduction: Gender differences in insulin resistance, body composition and lipid profile are well known and related to sex steroid hormones. In this study, we examine the metabolic profile of transsexual persons undergoing drastic sex steroid changes, during the first year of hormonal therapy.Design: This research is part of a prospective intervention study conducted in several European gender teams (Ghent, Oslo, Amsterdam, and Florence).<p class="...

Objective: assessment of endocrine system profile featuring hormonal and metabolic parameters in persons affected by the ChNPP accident with parathyroid disorders. Methods and results: Patients treated in the Department of Radiation Endocrinology in 2019-2020 were selected (n=150) by the method of blind sampling in accordance with the study objective. Study sample included the 100 subjects (50% females, 50% males) were affected by the ChNPP acci...

Objective: To evaluate the chance of developing new cases of Type 2 diabetes mellitus (DM) in obese people in the population sample of the city of Novosibirsk aged 45–69 years.Materials and methods: The analysis included 2464 people, including 586 (23.7%) men and 1878 (76.2%) women without DM. This sample was formed from the base of the international project HAPIEE surveyed from 2003 to 2005. When conducting a re-screening of the same sample in 2006...