Endocrine Abstracts

Background: Uncontrolled diabetes mellitus in ketoacidosis, as well as other kinds of metabolic acidosis, are major risk factors for mucormycosis. As the frequency of diabetes mellitus increase, so does the number of individuals at risk for this lethal infection. However, a lack of symptoms could lead to a delay in diagnosis. The aim of this paper is to study the clical features of otologic mucomycosis and to analysis the impact ketoacidosis the disease’s course.<p cl...

Introduction: Hypovitaminosis D is prevalent in children with growth hormone deficiency. Infants and young children are special risk groups of vitamin D deficiency due to their rapid growth with high nutritional requirements. The lack of early diagnosis and adequate treatment have adverse outcomes. It impairs particularly bone maturation and increases metabolic risk. The purpose of our study is to assess the vitamin D status of children followed up for GHD in the Endocrinology...

Background: Serum total cortisol responses to the short Synacthen® test (SST) are used to confirm or refute a diagnosis of adrenal insufficiency. Salivary cortisol measurement offers a non-invasive alternative and has the potential advantage of evaluating free, bioavailable cortisol. However, reference ranges and its performance in the investigation of suspected hypoadrenalism (SH) have not been firmly established.Aims: 1....

Background: Diagnosis of adrenal hypofunction requires a high index of suspicion. A frequent cause is iatrogenic glucocorticosteroid prescribing hence the need for a clinical review after a prolonged course.Aim: A review of glucocorticosteroid prescribing and auditing SST outcomes in a large private hospital.Methods: Electronic records over an 18 month period were analysed for SST results, patient demogra...

Aims and hypothesis: The aim of this study is to determine the baseline knowledge of diabetes and its management within two Psychiatric Crisis Resolution Teams based at NELFT NHS Foundation Trust. We hypothesise that attendance to diabetes seminars will lead to better knowledge of the condition’s management.Background: A 2014 NHS survey found that 6% of people with mental health conditions also suffered from diabete...

Background: Neuroglycopenic symptoms in insulinoma could persist for years before localising the source of endogenous hyperinsulinaemia. 90% of insulinomas are sporadic, solitary and < 2 cm in diameter, and can be associated with multiple endocrine neoplasia-1 (MEN-1). Insulinoma is an emerging clinical entity with a huge diagnostic challenge as tumour growth varies from months to years before tumour localisation.<p class="abstext...

Background: Despite new, albeit draft, international guidelines there remains limited data and guidance on the non-cardiac obstetric management and outcomes in women with Turner Syndrome (TS).AIMS: This retrospective single centre audit aimed to assess the maternal and fetal outcomes in a large single centre cohort.METHODS: We identified 110 women under our care with TS. Of these, 28 women had attempted to achiev...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Introduction: Graves’ disease is an autoimmune disorder of the thyroid gland causing over-production of thyroid hormone. Although this disorder can lead to systemic changes throughout the body, the most common extrathyroid manifestation of Graves’ disease is ophthalmopathy. Patients can have significant ocular prominence from the increase in intraconal and extraconal fat and muscular hypertrophy. This can lead to vision changes, decreased ocular motilit...

Respiratory muscle weakness and diaphragmatic failure is a rare presentation of hypercortisolism. We report a case of Cushing’s syndrome in a 60-year-old female with history of rheumatoid arthritis, biliary cirrhosis and hypothyroidism. She presented to the Respiratory Physicians with progressive worsening of shortness of breath. Clinical assessment excluded infective pathology, cardiac failure or asthma. Pulmonary function tests (PFT) showed re...