Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is a commonly encountered endocrine pathology. Asymptomatic renal stones have been reported in 7-22% of patients. NICE guideline (NG132) published in May 2019 on PHPT recommends renal US in all patients. The value of renal ultrasound for all patients with PHPT has been debated. This audit aims to compare local practice to NICE guideline (NG132) and to see if a tailored approach for renal ultrasound would be safe, practical and e...

Introduction: Growth hormone secretogogues (GHS) are popular among body building communities as muscle bulking agents. We present an interesting case of new onset diabetes induced by a combination of GHS and selective androgen receptor modulators (SARMs).Case report: A 34-years body builder was referred by his GP due to a 3-week history of polyuria, polydipsia and fatigue. He had recently used one cycle of a combination tablet which contained Ibutamoren ...

Background: High-grade neuroendocrine neoplasms (HG-NENs) are a heterogenous and biologically aggressive rare subset of NENs. Few therapeutic options are available to metastatic HG-NENs. To date, first line treatment is platinum- or temozolomide-based chemotherapy which provide modest benefits in overall survival (OS) and progression free survival (PFS). Given the promising activity of immunotherapy across several cancer types, our center initiated a phase II trial of pembroli...

Introduction: Adrenocortical carcinoma (ACC) is one of the most aggressive endocrine malignancies and confers a poor prognosis in advanced stages. Effective treatments are lacking. The results of immune checkpoint inhibition were disappointing with few responders only deriving clinical benefit. For the development of novel immunotherapies such as tumor vaccines and T cell-based treatments, target identification is essential. Tumor-specific mutant neoantigens that may be recogn...

Background: The Covid 19 pandemic has significantly changed people’s lives. For patients with chronic diseases, social isolation and distancing have become a provocative factor in metabolic control disorders of varying degrees. Patients avoided hospital visits as much as possible due to fear of infection. Also for the representatives of the medical field, the pandemic has become the basis for new ways of consulting patients (remote, teleconsultation). The aim of the study...

Introduction: Poor adherence to prescribed diabetic medication is a major contributor to disparities in effective glycemic control among patients with type 2 diabetes mellitus. The purpose of this study was to investigate the association between health literacy level and adherence to diabetic medications among this population.Methods: A cross-sectional survey enrolled 66 patients medically treated for type 2 diabetes mellitus. Patients with dementia synd...

Introduction: Past years with increasing of duration of life, improving of treatment and increasing of life longevity and new knowledges about Diabetes Mellitus pathogenesis and treatment rise interest to reproduction in these women, especially with type 1 DM. Well known, that late puberty, abnormal menstrual cycle, pregnancy and childbirth pathology, infertility. The aim of our study was investigate the functional state of reproductive system in woman with DM1.<p class="a...

Background: Acromegaly is a neuroendocrine disease that occurs with slowly progressive symptoms, which leads to delayed diagnosis and the development of complications. Arthropathy is one of such complications, which is accompanied by severe pain and significantly worsens the quality of life. The main attention of researchers is devoted to the pathology of the hip, knee and hand joints. At the same time, the study of the shoulder, acromioclavicular, costovertebral joints in acr...

Introduction: Hypophysitis is a rare condition corresponding to a chronic inflammation of the pituitary gland, The clinical and radiological signs are not specific and the pathogenesis remains poorly elucidated. The aim of our work is to report the clinico-radiological aspects of hypophysitis.Material and Methods: This is a retrospective descriptive study of 09 patients hospitalized in the department of Endocrinology-Diabetology-Nutrition of Mohammed-VI ...

Case history: A 67-year-old lady was referred to endocrinology with an 8-year history of mild hyperparathyroidism with Parathyroid hormone of 7.4 -15.3 pmol/l (Normal -1.95-8.49). Her corrected calcium ranged from 2.46-2.66 mmol/l (Normal 2.2 -2.62), phosphate 0.63 -1.0 mmol/l (normal 0.8-1.5), normal renal function and normal vitamin D. Her urine calcium to creatinine ratio was 0.7 mmol/mmol (Normal 0-0.4).Investigations and treatment: She had myalgia d...