Endocrine Abstracts

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the reduction of thyroid volume after pre-treatment adjunct of rhTSH in patients with non-toxic goitre with low RAIU.Material and methods: We treated 36 patients; (28 female, 8 male) aged 35–77 years. Initial 24 h RAIU was ranged between 5 and 17%, and thyroid volume ranged between 42 and 128 ml. Twelve patients had compressive symptoms. Malignant changes were exclu...

Hydrocortisone is the standard replacement therapy in patients with primary or secondary adrenal insufficiency (AI) but there is no current consensus on the most appropriate replacement dose and the extent to which this varies between individuals. This study examines inter-individual variability in cortisol metabolism in patients taking hydrocortisone therapy and investigates the relationship between plasma and salivary concentrations.Subjects and Method...

Background: Improved management for patients with cyanotic congenital heart disease (CCHD) has led to prolonged lifespan and an increase in patients with CCHD presenting with pheochromocytoma and paraganglioma (PPGL) has been noted. PPGL susceptibility genes including VHL, SDH(x), FH, EPAS1 have been connected to a common signaling pathway that activates hypoxia-inducible factors. 4 of 5 patients with CCHD and PPGL were previously noted to have a somatic gain-of-function mutat...

INTRODUCTIONTwelve prepubertal children (7 boys and 5 girls) who had been continuously using I.C.S. for at least 3 to 5 years in a prescribed dose of at least 500-800 micrograms per day were included in the study. Age ranged from 4 to 11 years. Duration of I.C.S. treatment ranged from 3 to 5 years. 20 children of the same population were used as controls. Bone mineral density (B.M.D.) of the lumbar spine (L2-L4) was measured by Dual Energy X-ray Absorpti...

Introduction: Close long-term follow-up of patients with pulmonary carcinoid (PC) tumours is important for detection of recurrence, which can occur many years after primary surgery. Expert consensus guidelines for management of PC were published in 2015 (European Neuroendocrine Tumor Society (ENETS)) and provide recommendations for follow-up type, frequency and duration. The LEAP Project aimed to describe current follow-up practices in the UK following publication of the guida...

The purpose of the study was to study the characteristics of the course of pregnancy and childbirth in women with prolactinomas, as well as the effect of pregnancy on the size and functional activity of prolactin-secreting pituitary adenomas.Materials and methods: 70 women with prolactinomas during pregnancy were examined. The age of the examined patients from 20 to 38 years (28.9 ± 0.5 years). The duration of the disease ranged from 3 months to 20 ...

The aim of our study was to evaluate the short term efficacy of radioiodine therapy (RIT) to reduce thyroid volume with minimal risk of hypothyroidism in patients with non-toxic nodular goitre. Material and Methods: We treated 120 patients, aged 20–76 years; (88%) of the studied groups were female and (12%) male. Initial 24 h RAIU was ranged between 22–44% and effective half-life was more than 3 days. Thyroid volume ranged between 42–170 ml. Malignant changes we...

Frequent measurement of blood glucose among hospitalized patients including those in critically ill areas is routinely practiced. Evidence suggests that tight glycaemic control among hospitalized patients reduced complications such as sepsis and has been shown to reduce length of stay. Most commercially available devices have not been assessed in critically ill patients, furthermore point of care (POC) glucose testing among paediatric populati...

Frequent measurement of blood glucose among hospitalized patients including those in critically ill areas is routinely practiced. Evidence suggests that tight glycaemic control among hospitalized patients reduced complications such as sepsis and has been shown to reduce length of stay. Most commercially available devices have not been assessed in critically ill patients, furthermore point of care (POC) glucose testing among paediatric populati...

Population and methodology: Patients with profound hyponatraemia (serum Na ≤125 mmol/l) admitted 1 November 2014 to 30 April 2015 were identified using hospital admission registry, laboratory’s database and qualitative data from the patients’ electronic records. Discharge summaries and death certificates were reviewed.Objectives: This is a retrospective audit set to asses: i) whether initial investigations of hyponatraemia were performed ...