Endocrine Abstracts

We report a 25 years old man who admitted in our department for primary hyperparathyroidism. He has previously been diagnosed with urolithiasis in 2006 and two pathological fracture of the humerus in 2009.Physical exam was normal laboratory findings showed hypercalcemia (4.06 mmol/l) associated to a high parathyroid hormone level (PTH: 1930 pg/ml).Ultrasound examination of the neck showed two enlarged parathyroid adenoma.<p cla...

Leptin stimulates osteoblastic cell proliferation, differentiation and mineralisation and inhibits osteoclast generation; leptin secretion and bone turnover are altered in adult growth hormone deficiency, a condition associated with osteoporosis. The aim of this study was to investigate leptin circadian rhythm and its association with bone turnover in untreated AGHD and following growth hormone replacement (GHR).We sampled peripheral venous blood at half...

Introduction: These last years have seen emerger identification of a large number of genes responsible of bone disease. La dyschondrosteosis: Leri weill is more important to know. It include short stature due to moderate micromelia mesomelic associated with a very characteristic deformity of the wrist: the Madelung deformity. This pathology is caused by haploinsufficiency of the SHOX gene, a gene essential in regulating the growth and remodeling of skeletal. We report observat...

Introduction: The incidence of hospitalised and fatal traumatic brain injury(TBI) is 235/100 000 with an average mortality rate of 15/100 000. A meta-analysis from 19 studies showed a prevalence of hypopituitarism after TBI of 27.5%.Case report: We report case of 72-year-old man, who suffered traumatic brain injury in October 2021, sustaining multiple skull fractures, with traumatic subarachnoid haemorrhage and subsequent pneumocephalus. He underwent bur...

A 17-year-old young lady presented with tiredness, weight loss, palpitations, hot flushes and irregular menstruation in April 2016 and her initial TFTs showed TSH <0.03 mU/l with a fT4 of 48.2 pmol/l. She was treated with carbimazole 40 mg daily and further investigation confirmed she had had Graves’ disease as TSH receptor antibodies (2.10 U/l), TPO antibodies (>1300 IU/ml), thyroid ultrasound scan demonstrated mildly enlarged and thyroiditis. She had only six period...

All domains of life feature diverse molecular clock machineries that synchronize physiological processes to diurnal environmental fluctuations. However, no mechanisms are known to cross-regulate prokaryotic and eukaryotic circadian rhythms in multi-kingdom ecosystems. We discovered that the intestinal microbiota, in both mice and humans, exhibits diurnal oscillations, leading to time-specific compositional and functional profiles over the course of a day. The active phase of t...

Major clinical events such as myocardial infarction and stroke are caused by atherosclerosis, a lipid-driven chronic inflammatory disease affecting the arterial wall. In recognition of the inflammatory drive in cardiovascular disease (CVD), a major interest has risen to complement current standards for high-risk patients by therapeutically targeting the inflammatory process. Prior to clinical application, therapeutic candidates are required to have a robust anti-inflammatory e...

BackgroundThere is a need to develop a highly sensitive and reliable immunoassay method for the determination of testosterone concentrations both in children and adults. Testosterone in blood is largely bound to proteins (sex hormone binding globulin and albumin). The unbound fraction of testosterone is considered to be the biologically active hormone which correlates more closely with the physiologically effective level of this hormone. It is postulated...

Radioiodine therapy is non-invasive, safe and cost effective method of therapy for reduction of goitre. We aimed to determine whether radioiodine therapy has benefit effect on the symptoms mimicking hyperthyroidism in nontoxic goitre patients.Material and methods: We studied 20 patients with non toxic nodular goitre, aged 42–79 years, 12 females and 8 males. All the patients complained of some symptoms of hyperthyroidism (palpitation, hot intoleranc...

There is no consensus regarding the optimum treatment of benign non-toxic goitre. Randomised studies have shown that levothyroxine has poor evidence of efficacy and is inferior to radioiodine therapy regarding goitre reduction.The aim of our study was to assess the efficacy of radioiodine therapy (RIT) to reduce thyroid volume with minimal risk of hypothyroidism in patients with non-toxic nodular goitre.Material and methods: During...