Endocrine Abstracts

Aim: To study patients with Bone metastases in papillary carcinoma thyroid and the role of I-131 ablation.Methods: Retrospective analysis of patients with papillary carcinoma of thyroid between 1960–2005 in our institution.Results: Of 1538 patients who had thyroid carcinoma, papillary carcinoma was seen in 1228 (79.8%), and 21 patients with papillary carcinoma (1.71%) had bone metastases. Seventy percent of them were between 4...

Intrathyroidal thymic carcinoma (ITTC) is a rare thyroid malignancy. Its histology resembles that of squamous cell carcinoma (SCC) of the thyroid. However, ITTC shows a much more favorable prognosis than SCC. We analyzed the backgrounds and clinicopathological features of 10 patients who treated with ITTC in our medical center. Five patients was male, and another five was female. The average tumor size was 4mm, and it ranged from maximum 68mm to minimum 13mm. In pre-operative ...

Background: Pulmonary-NETs are classified in low-grade typical carcinoid (TC), intermediate-grade atypical carcinoid (AC), and high-grade large cell carcinoma (LCNEC) and small cell carcinoma (SCLC). However, the proportion of pulmonary-NETs with similar histology that behave quite differently is not negligible. Recent studies favour the use of the proliferation marker Ki67.Aim: To evaluate the utility of Ki67 for predicting metastasis in a cohort of pat...

Background: Development of multi-steroid profiling allows comprehensive investigation into the different branches of steroid metabolism. Immunoassays only allow analysis of a single steroid per assay and suffer from problems with specificity due to cross reactivity of similar steroids. Liquid-chromatography mass spectrometry has the specificity to analyse multiple steroids in a single experiment and the dynamic range to quantify steroids at high concentrations such as those ob...

Background: Erectile dysfunction affects nearly half of men with type 2 diabetes (T2DM), and one-third of diabetic men have hypogonadism1. As an add-on to TRT in hypogonadal men with T2DM, Liraglutide may improve erectile function2, and dulaglutide decreased the incidence of moderate and severe ED in T2DM3.Study aims: To assess the GLP-1RA effect in T2DM men complaining of ED treated with both liraglutide and dulaglutide ...

A major cause of morbidity is post COVID-19 complications. The symptoms of carbohydrate dysfunction can be due to has relationship with coronavirus disease. In patients with chronic disorders after SARS-CoV-2 infection, aggravation of pre-existing symptoms has also been noticed. Diabetes insipidus (DI) may be at risk of dysnatraemia when developing respiratory complications of COVID-19. Particularly, the combination of two or more concurrent disorder is a major problem in pati...

Introduction: Most brand-name drugs do not differ that much from their generic counterparts, so switching between the two is not an issue. Levothyroxine, however, is an exception. The question of generic equivalency of levothyroxine products has remained unanswered for several decades. The purpose of the present study was to learn whether there is a difference of dosage between brand-name and generic levothyroxine in patient with well controlled primary hypothyroidism<p cl...

Introduction: Treatment of primary hypothyroidism relies on a daily intake of levothyroxine, which dosage is determined first by the weight then by TSH levels monitoring. The daily dosage can vary with the cause of the hypothyroidism and the weight. The aim of our study was to determine if the adherence was a factor influencing the dosage of levothyroxine in a group of well-controlled hypothyroid patients.Method: We performed a cross-sectional study incl...

Background: Spinal cord injury (SCI) can lead to dramatic physiological changes which can be a factor in developing secondary health conditions and might be reflected in biomarker changes in this elevated risk group. We focused specifically on the endocrine and inflammation profile differences between SCI and able-bodied individuals (ABI). Objectives: To determine the differences in inflammatory and endocrine markers profiles between individuals with SCI...

Background: Pregnancy is a physiological state characterised by enhanced thyroid hormone production resulting in increased demand for iodine. Iodine deficiency during pregnancy, is therefore, considered to be a risk factor for adequate growth and development in offspring. However our understanding of thyroid hormone homeostasis in iodine deficient environment is limited.Objectives: 1)To assess the current iodine status in pregnant women from an endemic z...