Endocrine Abstracts

Diagnostic procedures reveal that majority of incidentally found adrenal tumours (adrenal incidentalomas, AI) appear to be benign adenomas. However, AI accompanying malignant tumours must be diagnosed very carefully to take a proper decision concerning their management. In the registry of the Department of Endocrinology in Warsaw, there are 1888 patients (1388 women, 500 men, F/M ratio 2.8) with AI, 10–87 years old. Primary malignant tumours were diagnosed in 155 patients...

Aim: The aim of our study was to evaluate the short-term (5 years) effect of radioiodine therapy (RAIT) on the achievement of euthyroidism, and prevention evolvement to overt hyperthyroidism.Material and methods: We treated 150 patients, aged 30–70 years; 54 patients with multinodular goitre (MNG), and 96 patients with autonomous nodule (ATN). Malignant changes were excluded in all nodules by fine needle aspiration biopsy. All the patients had serum...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage. We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with Graves’ Disease.Material and methods: We studied 30 patients with Graves’ disease, aged 18–48 years. 12 normal adult volunteers were studied as control group. All the patients were treated unsuccessfully by antithyroid drugs. The effect...

Background: Hypoglycaemia frequently occurs in hospital inpatients with diabetes mellitus. With better vigilance amongst healthcare staff, episodes of hypoglycaemia could be prevented and with better awareness of the treatment process, early reversal of hypoglycaemia could avert the development of adverse events in these patients. This study aimed to assess the management of hypoglycaemia in hospital inpatients.Methods: This was a retrospective study of ...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage.We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with toxic nodular goitre.Material and methods: We studied 40 patients with toxic nodular goitre, (31 female, 9 male), aged 21–65 years. 12 normal adult volunteers (age and sex-matched) were studied as control group. All the pati...

CHARGE syndrome describes a pattern of birth defects which occurs in about one in every 9–10 000 births worldwide. It consists of a combination of congenital malformations: coloboma, heart defect, choanal atresia, delayed development, genital hypoplasia, ear abnormalities, and/or hearing loss defect. Casual mutations involve the chromodomain helicase DNA-binding protein-7 (CHD7). Gene locus 8q12.1, 7q21.1. The phenotype can also be caused by mutation in the semapho...

Introduction: Children with pseudohypoparathyroidism (PHP) can have a broad range of phenotypic features and biochemical abnormalities. The heterogeneity of this patient group prompted us to review the clinical features of these children in our service.Methods: We recorded the mode of presentation, clinical features, growth pattern, biochemical profile and progress of 13 paediatric patients with PHP and hypocalcaemia under review in our service over a 11...

The factors influencing the final outcomes of 131I therapy are indefinitely known, besides its practical use since more than 60 years. One of the considered factors affecting the results of 131I therapy is iodine metabolism.Aim: The aim of the study was the evaluation of the iodine uptake and the effective half-life of 131I influence on the result of radioactive iodine therapy in patients treated due to Graves’ hyper...

Oxidative stress plays an important role in hyperthyroidism induced – tissue damage.We aimed to determine whether radioiodine therapy (RIT) has benefit effect on the oxidant and antioxidant status in subclinical hyperthyroidism.Material and methods: We studied 40 patients with untreated subclinical hyperthyroidism, (33 female, 7 male), aged 23–78 years; 14 patients with multinodular goitre, and 25 patients with solitary a...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and skeletal systems and prevent evolvement to overt hyperthyroidism.Material and methods: We treated 630 patients, aged 30–70 years; 85% of them were female and 15% male; 220 patient with multinodular goitre (MNG), and 310 patient with autonomous nodule (ATN). Some of the p...