Endocrine Abstracts

Context: Mosaicism is a feature of several inherited tumor syndromes but is rarely systematically looked for in routine. MEN1 is an autosomal dominant hereditary syndrome characterized by several endocrine tumors affecting parathyroids, pancreas, and anterior pituitary most of the time, due to inactivating mutations in the MEN1 gene. Few cases of mosaicism in Multiple Endocrine Neoplasia type 1 (MEN1) have been described. MEN1 mosaicism is probably under-diag...

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor, [18...

Background: Many questions concerning Turner Syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. Most controversials regard tumors. Very few data are available on thyroid carcinoma and no specific screening protocol of monitoring is advised in the current official guidelines. This long-term cohort study was primarily aimed at estimating the incidence and time to comorbid conditions along the life course, inc...

Introduction: Although appendicitis occurs in approximately 1:1000 pregnancies, appendiceal neuroendocrine neoplasm (ANEN) diagnosis during pregnancy is very rare. Data on presentation, treatment and prognosis is scarce.Aim: To describe ANEN cases diagnosed during pregnancy.Materials and Methods: A retrospective appraisal of 7 consecutive ANEN patients diagnosed during pregnancy from four Israeli tertiary medical centers and compar...

Relevance: There is a search for candidate genes that contribute to the progression of atherosclerosis in patients with diabetes mellitus. It has been suggested that the FABP2 Ala54Thr polymorphism may be associated with the risk of atherosclerosis.Objective: To evaluate the relationship between polymorphism of the intestinal fatty acid-binding protein (FABP2) gene Ala54Thr with peripheral atherosclerosis in patients with type 2 diabetes mellitus.<p ...

Target.: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to T&Rcy;&Acy; for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - ...

The purpose of the study: Is to study features of cardiovascular complications in patients with Cushing syndrome in the Republic of Uzbekistan (RUz).Material and research methods: In the period of 2002 to 2021, 317 patients were installed with the following clinical forms of Cushing syndrome (CS): 1) ACTH-dependent CS (ACTH-DCS) - 258 (81.3%) patients, of which women -174 (54.8%), men - 84 (26.4%), 2) ACTH independent CS (ACTH-iCS) -51 patients (16.08%) ...

Target: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to T&Rcy;&Acy; for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - 8...

Aim: – to study the functional status of pituitary-gonades-cortex (PGC) axis in women with Cushing syndrome (CS)Materials and methods: Weevaluated 25 women with ACTH-depended CS without other associated pathology. Mean age of patients was 28,3 years-old\. All patients have complaints to amenorrhea and primary infertility. Control group constituted by 20 healthy women with same age All patients underwent clinical and biochemical evaluations including...

The goal of this study is to examine the role of surgery in the treatment of Graves’ disease and to assess the surgical outcomes.Methods: We present the results of a retrospective analysis of 31 Graves’ disease cases operated on in the ENT and cervico-facial surgery departments of Farhat Hached Sousse Hospital during a six-year period [2015-2021]. Our group consisted of 05 males and 26 women. The average age ranged from 12 to 70 years. Between ...