Endocrine Abstracts

Introduction: WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla. Almost all pheochromocytomas produce catecholamines. An annual incidence of this tumor in the general population is estimated at 3–8 cases/million/year. 40–50% of patients with pheochromocytoma are characterized by sustained hypertension, a similar percentage – only by paroxysmal hypertension and up to 10% are normotensiv...

Most of the patients with the benign cold nodule refuse surgical operation. Radioiodine therapy (RIT) is the choice for these patients. The aim of our study was to evaluate the efficacy of radioiodine therapy to reduce thyroid volume in patients with cold nodule by the use of two doses of radioiodine.Methods: We treated 40 patients with non-toxic nodular goitre with large cold nodule, aged 18 and 48 years; initial 24 h radioiodine uptake (RAIU) was range...

Growing interest in the role of vitamin D in many disease conditions as well as wide availability of vitamin D assays has led to a marked increase in its measurement. Although there are multiple circulating metabolites of vitamin D, those of interest are 25-hydroxyvitamin D2 and D3 and measurements of their relative concentrations is considered helpful. We reviewed vitamin D levels (D2 and D3) obtained on our patient population visiting a large teaching hospital.<p class="...

Introduction: Calcitonin is the main MTC marker. However, it has limitations: rapid in vitro degradation, a concentration-dependent biphasic half-life, presence of different isoforms and high cost of a single trial. Other markers of MTC can be procalcitonin and ProGRP.Aim: The aim of the study was to evaluate the diagnostic performance of marking the levels of procalcitonin and ProGRP in monitoring patients with MTC.Material...

Aim: The aim of the study was the evaluation of the TSHRAb level changes and the comparison with thyroid function in patients with Graves’ disease treated with 131I 10 years ago.Material and methods: The study has been conducted in 67 patients (57 women, 10 men) aged 27–72 y (mean 48 years) with Graves’ disease.All patients were treated with 131I due to hyperthyroidism confirmed by fT3, fT4 and ...

Aim: The aim of the study was the evaluation of the relationship between thyroid size and the result of radioactive iodine therapy in patients treated due to Graves’ hyperthyroidism.Material and methods: The study group included 150 subjects (127 M and 23 F), aged from 20 to 78 years (mean 48.33 years) at the moment of 131I therapy.In all patients the thyroid technetium-99m scan and determination of the serum levels...

In 1976, aged twenty, Mr A J was diagnosed with a cerebral haemangioblastoma, which was successfully removed. His father died from renal cell carcinoma and a Pheochromocytoma, raising the possibility of VHL syndrome. Genetic screening was positive but no follow-up was provided.In 2004, aged 48, he presented with a two year history of persistent diarrhoea. A CT scan revealed a left sided 1.7 cm adrenal adenoma. Serial 24 h urine metadrenaline ranged betwe...

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the achievement of euthyroidism and reduction of thyroid volume, in patients with toxic nodular goitre (TNG).Material and methods: During the last 7 years, we treated 3800 patients with TNG, aged 30-70 years; 82% female and 18% male; 2200 patients with multinodular goitre (MNG) and 1600 with autonomous toxic nodule (ATN); thyroid volume ranged between 16 and 130 ml (30% ...

Mutations in the HSD11B2 gene explain the syndrome of apparent mineralocorticoid excess (AME), which is characterised by severe hypokalaemic hypertension. Cortisol acts as a mineralocorticoid through failure of its inactivation to cortisone by 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). Patients are diagnosed by a raised THF+allo-THF/THE ratio. To date, approximately 30 mutations have been described in HSD11B2. Recently, three apparently unrelated kindreds with A...

Introduction: Cord blood gases are measured following partition and are used as surrogate markers in the assessment of fetal oxygenation status at delivery and in identification of risk for neonatal encephalopathy. Low maternal prolactin levels were associated increased risk of respiratory distress syndrome. This study measured cord blood prolactin levels and correlated values with blood gases to examine possible value in assessment of fetal stress during deli...