Endocrine Abstracts

Introduction: Diabetes mellitus (DM) is an expected condition in Cushing syndrome (CS) but there are few data about prevalence and factors associated to occurrence of DM in these patients.Objective: To determine the main aspects of DM in CS through a systematic review (SR) of the literature.Methods: MEDLINE and LILACS were searched for studies published until March, 2016. Search strategy comprised the terms “Diabetes Mellitus&...

Background: The inflammation of the pituitary gland known as hypophysitis. It is a rare disease accounting for approximately 0.24–0.88% of all pituitary diseases. Main forms of hypophysitis are histologically classified as lymphocytic, granulomatous, IgG4 related and xanthomatous. We aim to present ourpatients of hypophysitis with clinical,laboratoryand radiological features.Methods: We retrospectively reviewed our database of 1293 patients diagnose...

Idiopathic Isolated ATCH deficiency (IIAD) is a rare cause of secondary adrenal insufficiency characterised by ACTH deficiency with otherwise intact pituitary function. Our objective was to describe the presentation, the autoimmune associations and diagnostic findings observed in IIAD. We present a case series of 19 cases of idiopathic Isolated ACTH deficiency which were identified from the National Pituitary Register in Ireland. A chart and biochemical review was performed to...

Background: Thyroid nodule in the pediatric age group is rare, but the rate of malignancy is much higher than adult population. Fine needle aspiration biopsy (FNAB) is an accurate test commonly used to determine whether thyroid nodules are malignant in adults. However, less is known about its diagnostic accuracy for this purpose in children.Aim: To characterize the outcomes of FNAB of nodular thyroid disease at a pediatric tertiary-care institution and t...

Background: Endemic goiter occurs frequently in iodine deficient areas. Our past medical survey revealed that goiter was endemic in Xinjiang, Northwestern China, because, several elderly Uygur subjects had goiter. In the present study, several medical parameters were compared between subjects with and those without goiter.Methods: Elderly Uygur (age, 65–70 years n=99) and very old Uygur subjects (age, >90 years n=111) were hosp...

Background: Myxedema coma is an uncommon but life-threatening condition of severe and decompensated hypothyroidism requiring early recognition and prompt treatment. The aim of this study is to describe the clinical features and identify factors associated with mortality of our patients diagnosed myxedema coma over the past 15 years.Materials and methods: Retrospective chart review of patients diagnosed and treated at King Chulalongkorn Memorial Hospital ...

Introduction: The approach for initial thyroid hormone suppression in patients who undergo surgery for differentiated thyroid cancer (DTC), is based upon the risk of disease recurrence. In particular, recent American Thyroid Association guidelines suggest to maintain TSH levels between 0.1 and 0.5 mU/l and less than 0.1 mU/l for patients with ‘intermediate’ and ‘high’ risk respectively. The aim of the study is to identify the major predictive factors of LT4...

Effective targeted therapy for advanced endocrine malignancies is a goal of modern endocrinology. We herein present promising results of the first phase of clinical part of European project (Gran-T-MTC) aimed to assess the safety of gastrin analogue CP04 (DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) i.v. administration in dose (50 μg) useful for translation to 177In-CP04 for PRRT. CP04 has been selected for MTC therapy based on a high CCK-2 receptor...

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on pain reduction and on improving the quality of life of the patient. Particularly patients with multiple metastatic lesions benefit from bone-targeting therapeutic radiopharmaceuticals....

The purpose of the study: To examine the incidence of neuroendocrine complications after RT of pituitary somatotropinomas.Materials and methods: Thirty patients surveyed after receiving radiation therapy (RT) at a dose of 45 g in 25 fractions a day. Of these, 21 (70%) females, 9 (30%) men. The age of patients ranged from 36–71 years. 37% of them had pituitary macroadenoma with para-, supra-, infrasellar growth. Duration of illness was on average 15 ...