Endocrine Abstracts

Background and aim: Patients with GH deficiency (GHD) have increased risk of cerebrovascular events. The aim of this study was to evaluate the rate and factors associated with the occurrence of stroke, a major cause of death and disability, in adults with GHD.Patients and methods: Data from 15,188 GHD patients treated with GH replacement therapy (GHRT) enrolled in KIMS were analyzed. Stroke incidence rates were compared to rates from the Oxford Vascular ...

Objective: Evidence shows type 1 diabetes leads to vascular damage and neuropathy. The purpose of this study was to perform a systematic review and a meta-analysis to asses the evidence of the effects of type 1 diabetes on hearing function.Methods: Three different electronic databases were used to identify eligible studies including a manual searching of references. The articles obtained were independently reviewed by two authors using predefined inclusi...

Introduction: There is paucity of data comparing bone densitometry and body composition in adult women with congenital adrenal hyperplasia (CAH) treated with glucocorticoids since childhood and the same parameters in healthy women of the same age and BMI.Methods: 20 women with classical CAH (35% simple virilizing, 65% salt losing), aged 16–45 years, had anthropometric, laboratorial and densitometry exam (DXA) for bone mineral density (BMD) (L1–...

Background: The prevalence of diabetes in South Korea has drastically increased, and 8.6–11.0% of Korean adults aged ≥30 years were suffering for the disease in the early 2000s, according to the Korea National Health and Nutrition Examination Survey.Objective: The present study was performed to estimate the incidence and prevalence of type 2 diabetes mellitus (T2DM) and its complications in South Korea using the Health Insurance Review and Ass...

Purpose: To improve methods of plastic closure of wound defects in patients with diabetic foot syndrome using skin flaps on vascular pedicle of the perforating vessels.Methods: The study involved patients with diabetes type 2 complicated with diabetic foot syndrome neuroischemic form. The study included 31 patients, 15 people in the study group and 16 people - the control group. Area wounds ranged from 3.8 to 21 cm2. Cleansing the wounds was p...

Aim: To analyze the effects of inositol administration on parameters related to glucose homeostasis.Material and methods: Systematic review and meta-analysis of articles published in Medline or Web of Science Until February 1, 2016. We included studies that met the following criteria: i) Randomized controlled clinical trials of inositol/inositol isomer supplementation against placebo in parallel design, ii) performed in humans, iii) with information abou...

Objective: To study epileptic seizures in patients with large and giant prolactinomas.Patients and methods: The study group included 45 patients with large prolactinoma (more 36 mm in diameter) and 23 patients with giant prolactinoma (more than 60 mm in diameter). 55 men and 13 women aged 16–67 years (mean 39). Patients were followed by hormone measurements, magnetic resonance imaging (MRI), electroencephalogram (EEG) and endocrinological, psychopat...

Endocrine disrupting chemicals (EDCs) are exogenous compounds that affect the endocrine system, disrupt the hormonal balance and consequently cause the adverse health effects in humans. These compounds persist and accumulate in the environment and can easily gain entry to the food chain. Peroxisome proliferator-activated receptor gamma (PPARγ) and its heterodimeric partner retinoid X receptor alpha (RXRα) are very often targets of EDCs. PPARγ play crucial role i...

Vitamin D receptor (VDR) signalling can be affected with a variety of compounds, both endo- or exogenous. However, any disruption of VDR transcriptional activity can exert severe physiological or pathophysiological outcomes. It is therefore of a great importance to have a reliable in vitro screening technique that would provide a tool for efficient identification of agonists and activators of human VDR. In the current work, we described two novel human reporter cell l...

Aim: The work was initiated to study prolactin levels in hormonally inactive pituitary adenoma by the size of the tumor.Material and methods: We examined 85 patients with hormonally inactive pituitary adenomas, 45 women and 40 men among them aged from 18 to 50 years (mean age 44.5±3.85 years). The disease duration from the onset to diagnosis based on the medical history and MRI ranged from 1 to 15 years.Results and discussion:...