Endocrine Abstracts

Introduction: Acromegaly is a rare disease with significant morbidity and mortality. Surgical treatment is the first line treatment for these patients, with remission rates of >85% for microadenomas and 40–50% for macroadenomas.Objectives: Our objective was to characterize patients with acromegaly followed in our department and evaluate remission status after surgery. We also aimed to determine remission related factors.Me...

Testosterone deficiency syndrome (TDS) may well contribute to a number of co-morbidities and multitude of symptoms which may affect one’s daily activities adversely. TDS prevalence in UK is 5:1000 and certain groups of patient’s are at higher risk of TDS, in particular elderly and patients with diabetes mellitus where 42% are known to have TDS. A retrospective audit was carried out to bench mark our practice in line with a publication of a recommended National/Europe...

Aim: Despite multiple dose injections some patients still fail achieving HbA1c target. We aimed to evaluate the effect of sitagliptin add on therapy to multiple dose insulin injections.Method: Data of 47 (seven males and 40 females) type 2 diabetic patients who had HbA1c over 7% were retrospectively evaluated. They were already treated with premix lispro or aspart insulin (n=28), glargine plus premeal regular or aspart or lispro insulin (n</...

Introduction: Primary hyperparathyroidism (pHPT) is the unregulated overproduction of parathyroid hormone resulting in abnormal calcium homeostasis. The prevalence has been reported to be ~21 cases/100 000 person-years. The mean age at diagnosis has remained between 52 and 56 years with female-to-male ratio 3:1. In ~85% of cases, pHPT is caused by a single adenoma, in 14% of hyperplasia and 1% is caused by malignant diseases. Association between pHPT and cardiovascular manifes...

Objective: To investigate performance of sex hormone binding globulin (SHBG) assays of different manufacturers and the effects of assay choice on calculated free testosterone (cFT).Methods: Anonymized serum samples of 113 men and 106 women were randomly selected from excess material from the routine clinical lab at the University Hospital of South Manchester. SHBG levels were measured using three different immunoassays (...

Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor,...

Comprehensive multi-steroid profiling offers a powerful tool for the investigation, diagnosis and management of steroidogenic disorders by simultaneously quantifying multiple steroids from several pathways of steroid biosynthesis and metabolism. Difficulties can arise when optimising chromatography and mass spectrometry conditions for many analytes in a single method. Low concentrations of ammonium fluoride have previously been shown to enhance the sensitivity of select analyt...

Introduction: There is a clinical need to develop better biomarkers for the monitoring of patients with neuroendocrine tumours (NETs), including for patients with multiple endocrine neoplasia (MEN). Chromogranins are widely used, as are individual hormones for specific syndromes. Neurone specific enolase (NSE), however, is measured less commonly and its utility is debatable.Aims: To assess the value of measuring NSE in the clinical management of patients...

Introduction: The use of Inferior Petrosal Sinus Sampling (IPSS) to differentiate between central and ectopic ACTH dependent Cushing’s, although requires expertise, is widely available. The value of adding prolactin measurement to that of ACTH to improve IPSS diagnostic accuracy remains controversial. We evaluated the impact of adding prolactin measurement to IPSS procedures at a large academic center.Methods: Leftover samples from patients who were...

Bladder Paragangliomas (PGLs) are a rare manifestation of sympathetic chain PGLs and occur in prone patients with SDH mutation.They often display an aggressive phenotype with metastatic disease and require long-term follow up. SDHB immunostaining plays a significant role in initial risk stratification and facilitating appropriate genetic testing. We report four cases illustrating diagnostic management and outcome issues in this rare neuroendocrine pathology; two with SDHB muta...