Endocrine Abstracts

Introduction: The aim of this study was to evaluate the association between a personal history of lactation and indices of subclinical atherosclerosis and arterial stiffness in postmenopausal women.Patients and methods: This cross-sectional study included 283 postmenopausal women. Sonographically assessed indices of vascular function [pulse wave velocity (PWV)] and vascular structure [intima-media thickness (IMT), atherosclerotic plaque presence] were te...

Introduction: Most of the work on the analysis of molecular genetic defects in pituitary adenomas devoted to the study of 1–2 candidate genes. The high-performance parallel sequencing is more promising.Materials and Methods: There were a total of 26 families (58 patients, 36 (62.1%) men and 22 (37.9%) women) with pituitary adenomas secretion of various types. The number of families with homogenous type was 17 (somatotropinomas 13, prolactinomas 2, c...

Objective: To evaluate the efficacy, safety and to determine the criteria for the glucocorticoid therapy scheme: intravenous pulse therapy followed by tablet form in prolonged regime in the treatment of active phase of endocrine ophthalmopathy (EOP).Materials and methods: 28 patients of both sexes (52 eyes) with endocrine ophthalmopathy in the active phase were included in the study. The average age – 43.4±10.6 years. The duration of the diseas...

Introduction: Malignant phaeochromocytomas are rare tumours, developed at the medulla and paraganglia. Their diagnosis is established by the presence of metastases of organs devoid of chromaffin tissue or by the appearance of neoplastic recurrence. They are characterized by a morbidity and mortality due to the effects of uncontrolled and important hypersecretion cathécolaminergique and resistance to conventional cancer treatments.Aim: Report the obs...

Background: Type 2 diabetes (T2D) and hypercortisolism associated with Cushing’s syndrome (CS) share clinical characteristics such as hypertension, dyslipidaemia, hyperglycaemia, and obesity. Several studies have recorded a relatively high prevalence of hypercortisolism in T2D, which may have therapeutic implications. The aim of this systematic review and meta-analysis was to assess the prevalence of hypercortisolism in T2D patients.Methods: Origina...

Adenomatoid tumors are relatively uncommon neoplasms of mesothelial origin, usually occuring in the male and female genital tracts. Rare extragenital adenomatoid tumor has been identified in adrenal gland. The differential diagnosis includes metastatic carcinoma and adrenocortical carcinoma.We present a case of 30 years old woman with incidentally radiological (ultrasound) finding of unilateral tumor in the right adrenal gland. CT and MRI were of great v...

Introduction: This is an audit on the outcome of children and young people (CYP) with Type 1 Diabetes with high HbA1c who were offered extra appointments with a paediatric diabetes specialist nurse (PDSN) over a three-year period at Harrogate District Hospital.Patient population: 26 CYP with Type 1 Diabetes with HbA1C more than 75mmol/mol, were offered extra diabetes clinic appointments with a PDSN.Audit Methodology: A retrospectiv...

Introduction: Hypothalamic obesity can be associated with multiple co-morbidie and is difficult to treatment\. There is little evidence regarding the effectiveness of currently available treatment for weight loss. We looked at the role of bariatric surgery on weight loss in patients with hypothalamic obesity at St George’s Hospital, London.Methods: Six patients with hypothalamic obesity had bariatric surgery. All patients had associated endocrine de...

It is known that the genetic similarity, embryonic and functional hypothalamic-pituitary-gonadal system has close correlation with hypothalamic-pituitary-thyroid axis. Recent research has suggested the existence of interactions between the gonad and the functional capacity of the thyroid.The study was performed on 93 cases admitted to the Endocrinology Clinic during 2005–2011, whose age ranged from 16–44 years. Correlate with clinical features ...

Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disease. The clinical heterogeneity may range from mild subtle hypoglycaemia to severe life threatening hypoglycaemia. The commonest genetic cause of congenital hyperinsulinism are mutations in the genes ABCC8 and KCNJ11 encoding the two subunits (SUR1 and Kir6.2 respectively) of the pancreatic β-cell KATP channel. In the Ashkenazi Jewish population two founder mutation...