Endocrine Abstracts

Background: Parathyroid carcinoma (PC) is a rare cause of primary hyperparathyroidism (PHPT), accounting for <1%, with an equal gender distribution and an average age of diagnosis in the fifth decade of life. The diagnosis of PHPT is based on the laboratory finding of high levels of immunoreactive PTH in the presence of severe hypercalcaemia. The only potentially curative treatment for PC is surgery. Early surgery is the most important factor for optimal outcome.<p cla...

Introduction: Congenital adrenal hyperplasia (CAH) varies significantly in clinical presentation and progression causing challenges in management. The ultimate goal of treatment is to achieve normal growth and development while avoiding adrenal crisis and hyperandrogenism.Aim: Our aim was to ascertain the current practice in the UK on CAH management in children and compare these with the endocrine society recommendations.Methods: A...

Introduction: Primary aldosteronism (PA) is one of the causes of hypertension. Blood aldosterone and the aldosterone/direct renin concentration (DRC) are routinely used as a screening test for PA.Aim of study: Whether it matters if aldosterone concentration is determined in serum or plasma samples?Material and methods: 145 healthy males, five females (blood donors) were investigated. In all subjects blood was collected into two tub...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism.Materials and methods: We treated 1600 patients refered to our department during the last 8 years, aged 23–77 years; 89% of them were females and 11% males; 520 patients with multinodular goitre (MNG), and 1080 patients with au...

Background and aims: Obese people have more risk for hypertension, Diabetes mellitus and cardiovascular disease. Obesity is a major health issue globally. So our aim is to estimate the prevalence of obesity and abdominal obesity in adult patients.Materials and methods: In our study total 150 adults (> 20 years of age) patients were included. They were selected randomly & examined for BMI (body mass index) and WHR (waist to hip ratio).<p class...

Introduction: Anaplastic thyroid carcinoma also known as undifferentiated carcinoma is a rare and highly aggressive malignant tumor. It continues to rank as one of the deadliest diseases worldwide and carries a very poor prognosis. It is an aggressive locoregional disease with a high metastatic capacity. There is no agreement with regards to the best treatment.Material and Methods: We reporteded 6 cases of anaplastic thyroid carcinomas treated in the ENT...

Summary: Objective: To study the clinical manifestations of musculoskeletal complications (MSC) of acromegaly, to improve the early diagnosis of the disease.Materials and methods: 150 patients with acromegaly were examined who were observed at the RSSPMC of Endocrinology during the period from 2000 to 2020. The age of patients ranged from 19 to 76 years and averaged 43 ± 8.6 years. Of these, 65 (43.3%) were men and 85 (56.7%) women. Moreover, the du...

Diagnosis and management of infants and children with sex steroid disorders requires fast and simultaneous assessment of several sex steroid metabolites in serum at low concentrations and on small sample volumes. Therefore, we developed a sensitive and selective TurboFlow-LC-MS/MS method for quantification of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in serum from pre-pubertal children.Total run time was 10.75 mi...

Introduction: It is believed that hypoglycemia in the elderly is a dangerous condition and may result in stroke and death. We observed five female patients with insulinoma and over 20-year-long survival.Material: The material includes five female with the diagnosis of insulinoma. Patients’ age ranged from 78 to 91 years while disease duration ranged from 21 to 34 years.Methods: In all the patients, the diagnosis of insulinoma ...

Introduction: Generously supported by IPSEN)-->Glucocorticoids (GC) have a stimulatory effect on neutrophils and an inhibitory effect on the other leukocyte subpopulations. A potential stimulatory effect on erythropoiesis has been also hypothesized. The aim of our study was to evaluate the effect of pasireotide treatment on hemochrome parameters in patients with endogenous pituitary-dependent glucocorticoid excess or Cushing’s d...